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Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis

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  • Sang Chul Park

    (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul 07441, Korea
    These authors (SC Park and I-H Park) contributed equally to this work.)

  • Il-Ho Park

    (Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital, Korea University College of Medicine, Seoul 08308, Korea
    Medical Device Usability Test Center, Guro Hospital, Korea University College of Medicine, Seoul 08308, Korea
    These authors (SC Park and I-H Park) contributed equally to this work.)

  • Joong Seob Lee

    (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Hallym Sacred Heart Hospital, Anyang 14068, Korea)

  • Sung Min Park

    (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Dongtan Sacred Heart Hospital, Hwaseong 18450, Korea)

  • Sung Hun Kang

    (Department of Biomedical Sciences, College of Medicine, Hallym University, Chuncheon 24252, Korea)

  • Seok-Min Hong

    (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Dongtan Sacred Heart Hospital, Hwaseong 18450, Korea)

  • Soo-Hwan Byun

    (Department of Oral & Maxillofacial Surgery, Dentistry, Hallym University College of Medicine, Hallym Sacred Heart Hospital, Anyang 14068, Korea)

  • Yong Gi Jung

    (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea)

  • Seok Jin Hong

    (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Dongtan Sacred Heart Hospital, Hwaseong 18450, Korea)

Abstract

The sinonasal microbiota in human upper airway may play an important role in chronic rhinosinusitis (CRS). Thus, this study aimed to investigate the human upper airway microbiome in patients with unilateral CRS, and compare the sinonasal microbiome of the unilateral diseased site with that of a contralateral healthy site. Thirty samples, 15 each from the diseased and healthy sites, were collected from the middle meatus and/or anterior ethmoid region of 15 patients with unilateral CRS during endoscopic sinus surgery. DNA extraction and bacterial microbiome analysis via 16S rRNA gene sequencing were then performed. Corynebacterium showed the highest relative abundance, followed by Staphylococcus in samples from both the diseased and healthy sites. Further, the relative abundances of Staphylococcus and Pseudomonas were significantly lower in samples from diseased sites than in those from healthy sites. Conversely, anaerobes, including Fusobacterium , Bacteroides , and Propionibacterium , were abundantly present in samples from both sites, more so in samples from diseased sites. However, the sites showed no significant difference with respect to richness or diversity ( p > 0.05). Our results indicate that CRS might be a polymicrobial infection, and also suggest that Corynebacterium and Staphylococcus may exist as commensals on the sinus mucosal surface in the upper respiratory tract.

Suggested Citation

  • Sang Chul Park & Il-Ho Park & Joong Seob Lee & Sung Min Park & Sung Hun Kang & Seok-Min Hong & Soo-Hwan Byun & Yong Gi Jung & Seok Jin Hong, 2021. "Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis," IJERPH, MDPI, vol. 18(18), pages 1-16, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9878-:d:639182
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    References listed on IDEAS

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    1. Jason Lloyd-Price & Anup Mahurkar & Gholamali Rahnavard & Jonathan Crabtree & Joshua Orvis & A. Brantley Hall & Arthur Brady & Heather H. Creasy & Carrie McCracken & Michelle G. Giglio & Daniel McDona, 2017. "Strains, functions and dynamics in the expanded Human Microbiome Project," Nature, Nature, vol. 550(7674), pages 61-66, October.
    2. Jason Lloyd-Price & Anup Mahurkar & Gholamali Rahnavard & Jonathan Crabtree & Joshua Orvis & A. Brantley Hall & Arthur Brady & Heather H. Creasy & Carrie McCracken & Michelle G. Giglio & Daniel McDona, 2017. "Erratum: Strains, functions and dynamics in the expanded Human Microbiome Project," Nature, Nature, vol. 551(7679), pages 256-256, November.
    3. Christoph A. Thaiss & Niv Zmora & Maayan Levy & Eran Elinav, 2016. "The microbiome and innate immunity," Nature, Nature, vol. 535(7610), pages 65-74, July.
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