IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2020i1p191-d470189.html
   My bibliography  Save this article

Incidence of Thyroid Cancer in Italian Contaminated Sites

Author

Listed:
  • Marta Benedetti

    (Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy)

  • Amerigo Zona

    (Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy)

  • Paolo Contiero

    (Environmental Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy)

  • Eleonora D’Armiento

    (Internal Medicine Unit, Department of Medico-Surgical Sciences and Biotechnologies, ICOT Hospital, University of Rome, 04100 Latina, Italy)

  • Ivano Iavarone

    (Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy)

  • AIRTUM Working Group

    (AIRTUM Working Group (AIRTUM Working Group members are listed in Appendix A).)

Abstract

Some human literature suggests a possible role of endocrine disruptors (EDs) exposure in thyroid cancer (TC) development. We investigated TC incidence in selected Italian National Priority Contaminated Sites (NPCS) with documented presence of EDs considered thyroid carcinogens. Adjusted Standardized Incidence Ratios (SIRs), with their 90% confidence intervals, were computed by gender, and age-specific groups (aged 15–39 years, and 40 years or over) for each NPCS in the period 2006 to 2013. In the age group of 15–39 years, a significant excess of TC risk was found in two NPCSs in males; non-significant excess risks were observed in four NPCSs in males, and in five in females. In the age group of 40 years and over, significant excess risks were found in six NPCSs in males and in seven NPCSs in females; non-significant excess risks were identified in two NPCSs in males and females. The findings of several excesses in incidence, mainly observed in adults aged 40 years or over, are suggestive of a possible adverse effect associated with residence in NPCSs, even if a role of other factors cannot be excluded, due to the adoption of an ecological study design. Future analytical studies are needed to clarify if EDs are a TC risk factor for individuals living in NPCSs.

Suggested Citation

  • Marta Benedetti & Amerigo Zona & Paolo Contiero & Eleonora D’Armiento & Ivano Iavarone & AIRTUM Working Group, 2020. "Incidence of Thyroid Cancer in Italian Contaminated Sites," IJERPH, MDPI, vol. 18(1), pages 1-16, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:191-:d:470189
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/1/191/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/1/191/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Marta Benedetti & Amerigo Zona & Eleonora Beccaloni & Mario Carere & Pietro Comba, 2017. "Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties," IJERPH, MDPI, vol. 14(4), pages 1-11, March.
    2. Francesca Gorini & Giorgio Iervasi & Alessio Coi & Letizia Pitto & Fabrizio Bianchi, 2018. "The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives," IJERPH, MDPI, vol. 15(9), pages 1-24, August.
    3. Maria Fiore & Gea Oliveri Conti & Rosario Caltabiano & Antonino Buffone & Pietro Zuccarello & Livia Cormaci & Matteo Angelo Cannizzaro & Margherita Ferrante, 2019. "Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review," IJERPH, MDPI, vol. 16(7), pages 1-18, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Letizia Pitto & Francesca Gorini & Fabrizio Bianchi & Elena Guzzolino, 2020. "New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way," IJERPH, MDPI, vol. 17(21), pages 1-18, October.
    2. Francesca Gorini & Elisa Bustaffa & Alessio Coi & Giorgio Iervasi & Fabrizio Bianchi, 2020. "Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence," IJERPH, MDPI, vol. 17(8), pages 1-46, April.
    3. Maria De Falco & Vincenza Laforgia, 2021. "Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland," IJERPH, MDPI, vol. 18(18), pages 1-18, September.
    4. Robert G. Poston & Ramendra N. Saha, 2019. "Epigenetic Effects of Polybrominated Diphenyl Ethers on Human Health," IJERPH, MDPI, vol. 16(15), pages 1-13, July.
    5. Young Ju Jin & Suk Woo Lee & Chang Myeon Song & Bumjung Park & Hyo Geun Choi, 2021. "Analysis of the Association between Female Medical History and Thyroid Cancer in Women: A Cross-Sectional Study Using KoGES HEXA Data," IJERPH, MDPI, vol. 18(15), pages 1-9, July.
    6. Francesca Gorini & Giorgio Iervasi & Alessio Coi & Letizia Pitto & Fabrizio Bianchi, 2018. "The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives," IJERPH, MDPI, vol. 15(9), pages 1-24, August.
    7. Mathilda Alsen & Vikram Vasan & Eric M. Genden & Catherine Sinclair & Maaike van Gerwen, 2022. "Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study," IJERPH, MDPI, vol. 19(20), pages 1-10, October.
    8. Francesca Gorini & Fabrizio Bianchi & Giorgio Iervasi, 2020. "COVID-19 and Thyroid: Progress and Prospects," IJERPH, MDPI, vol. 17(18), pages 1-5, September.
    9. Tingting Ma & Linwei Liu & Wei Zhou & Like Chen & Peter Christie, 2019. "Effects of Phthalate Esters on Ipomoea aquatica Forsk. Seedlings and the Soil Microbial Community Structure under Different Soil Conditions," IJERPH, MDPI, vol. 16(18), pages 1-19, September.
    10. Angela Giuliani & Mariachiara Zuccarini & Angelo Cichelli & Haroon Khan & Marcella Reale, 2020. "Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact," IJERPH, MDPI, vol. 17(16), pages 1-43, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:191-:d:470189. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.