IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i9p1834-d165671.html
   My bibliography  Save this article

The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives

Author

Listed:
  • Francesca Gorini

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Giorgio Iervasi

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Alessio Coi

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Letizia Pitto

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

  • Fabrizio Bianchi

    (Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy)

Abstract

In the last decades, the incidence of thyroid cancer has increased faster than that of any other malignant tumor type. The cause of thyroid cancer is likely multifactorial and a variety of both exogenous and endogenous has been identified as potential risk factors. Polybrominated diphenyl ethers (PBDEs), used since the 1970s as flame retardants, are still widespread and persistent pollutants today, although their production was definitely phased out in the western countries several years ago. Polybrominated diphenyl ethers are known endocrine disruptors, and the endocrine system is their primary target. Whereas animal studies have ascertained the ability of PBDEs to affect the normal functionality of the thyroid, evidence in humans remains inconclusive, and only a few epidemiological studies investigated the association between exposure to PBDEs and thyroid cancer. However, a number of clues suggest that a prolonged exposure to these chemicals might act a trigger of the most common malignancy of the endocrine system, whereas further studies with an advanced design are suggested.

Suggested Citation

  • Francesca Gorini & Giorgio Iervasi & Alessio Coi & Letizia Pitto & Fabrizio Bianchi, 2018. "The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives," IJERPH, MDPI, vol. 15(9), pages 1-24, August.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:9:p:1834-:d:165671
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/9/1834/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/9/1834/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Xuemin Zhao & Hailong Wang & Jing Li & Zhongyan Shan & Weiping Teng & Xiaochun Teng, 2015. "The Correlation between Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Hormones in the General Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-17, May.
    2. Te-I Weng & Mei-Huei Chen & Guang-Wen Lien & Pai-Shan Chen & Jasper Chia-Cheng Lin & Cheng-Chung Fang & Pau-Chung Chen, 2017. "Effects of Gender on the Association of Urinary Phthalate Metabolites with Thyroid Hormones in Children: A Prospective Cohort Study in Taiwan," IJERPH, MDPI, vol. 14(2), pages 1-23, January.
    3. Marta Benedetti & Amerigo Zona & Eleonora Beccaloni & Mario Carere & Pietro Comba, 2017. "Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties," IJERPH, MDPI, vol. 14(4), pages 1-11, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Robert G. Poston & Ramendra N. Saha, 2019. "Epigenetic Effects of Polybrominated Diphenyl Ethers on Human Health," IJERPH, MDPI, vol. 16(15), pages 1-13, July.
    2. Marta Benedetti & Amerigo Zona & Paolo Contiero & Eleonora D’Armiento & Ivano Iavarone & AIRTUM Working Group, 2020. "Incidence of Thyroid Cancer in Italian Contaminated Sites," IJERPH, MDPI, vol. 18(1), pages 1-16, December.
    3. Francesca Gorini & Elisa Bustaffa & Alessio Coi & Giorgio Iervasi & Fabrizio Bianchi, 2020. "Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence," IJERPH, MDPI, vol. 17(8), pages 1-46, April.
    4. Letizia Pitto & Francesca Gorini & Fabrizio Bianchi & Elena Guzzolino, 2020. "New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way," IJERPH, MDPI, vol. 17(21), pages 1-18, October.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Vishal Singh & Javier Cortes-Ramirez & Leisa-Maree Toms & Thilakshika Sooriyagoda & Shamshad Karatela, 2022. "Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review," IJERPH, MDPI, vol. 19(13), pages 1-20, June.
    2. Maria De Falco & Vincenza Laforgia, 2021. "Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland," IJERPH, MDPI, vol. 18(18), pages 1-18, September.
    3. Annette M. Krais & Christina Andersen & Axel C. Eriksson & Eskil Johnsson & Jörn Nielsen & Joakim Pagels & Anders Gudmundsson & Christian H. Lindh & Aneta Wierzbicka, 2018. "Excretion of Urinary Metabolites of the Phthalate Esters DEP and DEHP in 16 Volunteers after Inhalation and Dermal Exposure," IJERPH, MDPI, vol. 15(11), pages 1-14, November.
    4. Liujia Fan & Lixin Wang & Kexin Wang & Fang Liu & Gang Wang, 2022. "Phthalates in Glass Window Films of Chinese University Dormitories and Their Associations with Indoor Decorating Materials and Personal Care Products," IJERPH, MDPI, vol. 19(22), pages 1-12, November.
    5. Marta Benedetti & Amerigo Zona & Paolo Contiero & Eleonora D’Armiento & Ivano Iavarone & AIRTUM Working Group, 2020. "Incidence of Thyroid Cancer in Italian Contaminated Sites," IJERPH, MDPI, vol. 18(1), pages 1-16, December.
    6. Xuemin Zhao & Shiqiao Peng & Yang Xiang & Yali Yang & Jing Li & Zhongyan Shan & Weiping Teng, 2017. "Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study," IJERPH, MDPI, vol. 14(3), pages 1-11, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:9:p:1834-:d:165671. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.