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The Asti Study: The Induction of Oxidative Stress in A Population of Children According to Their Body Composition and Passive Tobacco Smoking Exposure

Author

Listed:
  • Giulia Squillacioti

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Valeria Bellisario

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Elena Grignani

    (Maugeri Scientific Clinical Institutes, 27100 Pavia, Italy)

  • Giulio Mengozzi

    (City of Health and Science of Turin, Molinette Hospital, 10145 Turin, Italy)

  • Giulia Bardaglio

    (SUISM, Structure of Hygiene, Sport Sciences and Physical Activities, headquarters of Asti, University of Turin, 10126 Turin, Italy)

  • Paola Dalmasso

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Roberto Bono

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
    SUISM, Structure of Hygiene, Sport Sciences and Physical Activities, headquarters of Asti, University of Turin, 10126 Turin, Italy)

Abstract

Obesity and exposure to second-hand tobacco smoking (SHS) may influence oxidative stress (OS) levels, especially in children. This study investigated body composition and SHS influence on OS induction in the paediatric population. The first purpose was identifying an appropriate BMI standard for adiposity assessment in OS investigations. Secondly, SHS and obesity were analysed as inductors of OS. The epidemiologic sample involved 330 children. Three BMI (body mass index) references (IOTF, CDC, and WHO) and an impedentiometric scale supplied body-composition measurements. Partecipants filled out a questionnaire and provided urinary samples for biomarker quantifications: isoprostane (15-F2t IsoP) and cotinine as OS and SHS biomarker, respectively. Obesity prevalence changed over different BMI references (14%, 21%, and 34% for IOTF, CDC, and WHO, respectively). Obese children, by IOTF, showed an increase of 56% in 15-F2t IsoP compared to those normal weight ( p = 0.020). Children belonging to the third and the fourth cotinine quartile compared to those of the first quartile had higher 15-F2t IsoP (1.45 ng/mg, 95% CI: 1.06–1.97, p = 0.020 and 2.04 ng/mg, 95% CI: 1.55–2.69, p < 0.0001, respectively). Obesity assessment in children requires appropriate BMI reference depending on research field. Both SHS exposure and obesity may increase OS in children.

Suggested Citation

  • Giulia Squillacioti & Valeria Bellisario & Elena Grignani & Giulio Mengozzi & Giulia Bardaglio & Paola Dalmasso & Roberto Bono, 2019. "The Asti Study: The Induction of Oxidative Stress in A Population of Children According to Their Body Composition and Passive Tobacco Smoking Exposure," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:3:p:490-:d:204469
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    References listed on IDEAS

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    1. Agnieszka Strzelak & Aleksandra Ratajczak & Aleksander Adamiec & Wojciech Feleszko, 2018. "Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review," IJERPH, MDPI, vol. 15(5), pages 1-35, May.
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    Cited by:

    1. Giulia Squillacioti & Valeria Bellisario & Stefano Levra & Pavilio Piccioni & Roberto Bono, 2019. "Greenness Availability and Respiratory Health in a Population of Urbanised Children in North-Western Italy," IJERPH, MDPI, vol. 17(1), pages 1-11, December.
    2. Markus Braun & Doris Klingelhöfer & Gerhard M. Oremek & David Quarcoo & David A. Groneberg, 2020. "Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children—An Overview in Research Insights of the Last Few Years," IJERPH, MDPI, vol. 17(9), pages 1-25, May.
    3. Roberto Bono & Giulia Squillacioti & Federica Ghelli & Marco Panizzolo & Rosanna Irene Comoretto & Paola Dalmasso & Valeria Bellisario, 2023. "Oxidative Stress Trajectories during Lifespan: The Possible Mediation Role of Hormones in Redox Imbalance and Aging," Sustainability, MDPI, vol. 15(3), pages 1-10, January.
    4. Roberto Bono & Valeria Bellisario & Roberta Tassinari & Giulia Squillacioti & Tilde Manetta & Massimiliano Bugiani & Enrica Migliore & Pavilio Piccioni, 2019. "Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    5. Valeria Bellisario & Rosanna Irene Comoretto & Paola Berchialla & Emanuele Koumantakis & Giulia Squillacioti & Alberto Borraccino & Roberto Bono & Patrizia Lemma & Lorena Charrier & Paola Dalmasso, 2022. "The Association between Greenness and Urbanization Level with Weight Status among Adolescents: New Evidence from the HBSC 2018 Italian Survey," IJERPH, MDPI, vol. 19(10), pages 1-10, May.
    6. Salome Sunday & Zubair Kabir, 2019. "Impact of Carers’ Smoking Status on Childhood Obesity in the Growing up in Ireland Cohort Study," IJERPH, MDPI, vol. 16(15), pages 1-12, August.
    7. Valeria Bellisario & Pavilio Piccioni & Massimiliano Bugiani & Giulia Squillacioti & Stefano Levra & Carlo Gulotta & Giulio Mengozzi & Alberto Perboni & Elena Grignani & Roberto Bono, 2019. "Tobacco Smoke Exposure, Urban and Environmental Factors as Respiratory Disease Predictors in Italian Adolescents," IJERPH, MDPI, vol. 16(20), pages 1-11, October.
    8. Hyun-Seung Rhyu & Kyung-Shin Park, 2019. "Effects of Telephone Follow-Up Intervention on %Body Fat, Inflammatory Cytokines, and Oxidative Stress in Obese Hispanic Children," IJERPH, MDPI, vol. 16(16), pages 1-9, August.
    9. Enrico Cocchi & Valeria Bellisario & Francesco Cresi & Claudio Plazzotta & Claudio Cassardo & Consolata Siniscalco & Licia Peruzzi & Roberto Bono, 2023. "Air Pollution and Aeroallergens as Possible Triggers in Preterm Birth Delivery," IJERPH, MDPI, vol. 20(2), pages 1-15, January.

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