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Oxidative Stress Trajectories during Lifespan: The Possible Mediation Role of Hormones in Redox Imbalance and Aging

Author

Listed:
  • Roberto Bono

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Giulia Squillacioti

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Federica Ghelli

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Marco Panizzolo

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Rosanna Irene Comoretto

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Paola Dalmasso

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Valeria Bellisario

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy
    Post Graduate School of Medical Statistics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

Abstract

Aging, a natural multifactorial process, increases Oxidative Stress (OS) and inflammatory responses. Sexual hormones could upregulate OS during lifespan, with opposite systemic effects: anti-oxidant protection and cellular pro-oxidant toxicity. Hormonal changes are crucial phases in human growth and aging, but their mediating role on OS is still incomplete. The main purpose of this work was to analyze the trend of OS during the lifespan and, in particular, during puberty and menopause. Data from standardized questionnaires and biological OS measurements (15-F2t-Isop) of 815 subjects (7–60 years old) from five previous studies (2009–2015) were analyzed. The age variable was categorized into two hormonal age windows: puberty and menopause. A regression model was performed to assess the association between 15-F2t-Isop and the hormonal age window, sex, weight, and smoking habits. The results showed a significant V-shape decrease of OS levels both during puberty [OR = −0.06 95% CI −0.07–−0.04, p = 0.41] and in menopause [OR = −1.01 95% CI −1.5–−0.5, p < 0.001], but only in females. Our results support the view that hormones, and specifically estrogen, could modulate OS, especially during puberty and menopause. The V-shape decreasing trend of OS may be related to intrinsic characteristics of estrogen, which is able to modulate and upregulate OS pro- and anti-oxidant mechanisms.

Suggested Citation

  • Roberto Bono & Giulia Squillacioti & Federica Ghelli & Marco Panizzolo & Rosanna Irene Comoretto & Paola Dalmasso & Valeria Bellisario, 2023. "Oxidative Stress Trajectories during Lifespan: The Possible Mediation Role of Hormones in Redox Imbalance and Aging," Sustainability, MDPI, vol. 15(3), pages 1-10, January.
    • Handle: RePEc:gam:jsusta:v:15:y:2023:i:3:p:1814-:d:1039321
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    References listed on IDEAS

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    1. Roberto Bono & Valeria Bellisario & Roberta Tassinari & Giulia Squillacioti & Tilde Manetta & Massimiliano Bugiani & Enrica Migliore & Pavilio Piccioni, 2019. "Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    2. Bedayah Amro & Maria Eugenia Ramirez Aristondo & Shaima Alsuwaidi & Basma Almaamari & Zeinab Hakim & Muna Tahlak & Arnaud Wattiez & Philippe R. Koninckx, 2022. "New Understanding of Diagnosis, Treatment and Prevention of Endometriosis," IJERPH, MDPI, vol. 19(11), pages 1-14, May.
    3. Giulia Squillacioti & Valeria Bellisario & Elena Grignani & Giulio Mengozzi & Giulia Bardaglio & Paola Dalmasso & Roberto Bono, 2019. "The Asti Study: The Induction of Oxidative Stress in A Population of Children According to Their Body Composition and Passive Tobacco Smoking Exposure," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    4. Valeria Bellisario & Pavilio Piccioni & Massimiliano Bugiani & Giulia Squillacioti & Stefano Levra & Carlo Gulotta & Giulio Mengozzi & Alberto Perboni & Elena Grignani & Roberto Bono, 2019. "Tobacco Smoke Exposure, Urban and Environmental Factors as Respiratory Disease Predictors in Italian Adolescents," IJERPH, MDPI, vol. 16(20), pages 1-11, October.
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