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Alcoholism: A Multi-Systemic Cellular Insult to Organs

Author

Listed:
  • Ucee Dguzeh

    (Department of Physiology, New Jersey Medical School Rutgers, 185 S Orange Ave, Newark, NJ 07103, USA
    These authors contributed equally to this work.)

  • Natasha C. Haddad

    (Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W Street, NW, #2309, Washington, DC 20059, USA
    These authors contributed equally to this work.)

  • Kathia T. S. Smith

    (Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W Street, NW, #2309, Washington, DC 20059, USA
    These authors contributed equally to this work.)

  • John O. Johnson

    (Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W Street, NW, #2309, Washington, DC 20059, USA)

  • Angelia A. Doye

    (Gwathmey Inc., Cambridge, MA 02138, USA)

  • Judith K. Gwathmey

    (Gwathmey Inc., Cambridge, MA 02138, USA
    School of Medicine, Boston University, Boston, MA 02215, USA)

  • Georges E. Haddad

    (Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W Street, NW, #2309, Washington, DC 20059, USA)

Abstract

Alcohol abuse can affect more than the heart and the liver. Many observers often do not appreciate the complex and differing aspects of alcohol’s effects in pathophysiologies that have been reported in multiple organs. Chronic alcohol abuse is known to be associated with pathophysiological changes that often result in life-threatening clinical outcomes, e.g., breast and colon cancer, pancreatic disease, cirrhosis of the liver, diabetes, osteoporosis, arthritis, kidney disease, immune system dysfunction, hypertension, coronary artery disease, cardiomyopathy, and can be as far-reaching as to cause central nervous system disorders. In this review article, we will discuss the various organs impacted by alcohol abuse. The lack of clear guidelines on the amount and frequency of alcohol intake, complicated by personal demographics, make extrapolations to real-life practices at best difficult for public health policy-makers.

Suggested Citation

  • Ucee Dguzeh & Natasha C. Haddad & Kathia T. S. Smith & John O. Johnson & Angelia A. Doye & Judith K. Gwathmey & Georges E. Haddad, 2018. "Alcoholism: A Multi-Systemic Cellular Insult to Organs," IJERPH, MDPI, vol. 15(6), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1083-:d:149275
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    References listed on IDEAS

    as
    1. Yue Zhou & Jie Zheng & Sha Li & Tong Zhou & Pei Zhang & Hua-Bin Li, 2016. "Alcoholic Beverage Consumption and Chronic Diseases," IJERPH, MDPI, vol. 13(6), pages 1-27, May.
    2. Hae-Dong Jang & Jae-Young Hong & Kyungdo Han & Jae Chul Lee & Byung-Joon Shin & Sung-Woo Choi & Seung-Woo Suh & Jae-Hyuk Yang & Si-Young Park & Chungwon Bang, 2017. "Relationship between bone mineral density and alcohol intake: A nationwide health survey analysis of postmenopausal women," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-11, June.
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    Cited by:

    1. Donatello Carrino & Jacopo Junio Valerio Branca & Matteo Becatti & Ferdinando Paternostro & Gabriele Morucci & Massimo Gulisano & Lorenzo Di Cesare Mannelli & Alessandra Pacini, 2021. "Alcohol-Induced Blood-Brain Barrier Impairment: An In Vitro Study," IJERPH, MDPI, vol. 18(5), pages 1-14, March.

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