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Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels

Author

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  • Katarina M. Jørgensen

    (Department of Clinical Science, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway
    Institute of Marine Research, P.O. Box 1870 Nordnes, N-5817 Bergen, Norway)

  • Ellen Færgestad Mosleth

    (Nofima AS, Osloveien 1, N-1430 Ås, Norway)

  • Kristian Hovde Liland

    (Nofima AS, Osloveien 1, N-1430 Ås, Norway
    Faculty of Science and Technology, Norwegian University of Life Sciences, NO-1430 Ås, Norway)

  • Nancy B. Hopf

    (Institute for Work and Health (IST), Universities of Lausanne and Geneva, CH-1066 Lausanne-Epalinges, Switzerland)

  • Rita Holdhus

    (Department of Clinical Science, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway
    Department of Medical Genetics, Haukeland University Hospital, P.O. Box 1400, N-5021 Bergen, Norway)

  • Anne-Kristin Stavrum

    (Department of Clinical Science, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway
    Department of Medical Genetics, Haukeland University Hospital, P.O. Box 1400, N-5021 Bergen, Norway)

  • Bjørn Tore Gjertsen

    (Center for Cancer Biomarkers (CCBIO), Department of Clinical Science, Precision Oncology Research Group, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway)

  • Jorunn Kirkeleit

    (Department of Clinical Science, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway
    Department of Global Public Health and Primary Care, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway)

Abstract

Altered gene expression in pathways relevant to leukaemogenesis, as well as reduced levels of circulating lymphocytes, have been reported in workers that were exposed to benzene concentrations below 1 ppm. In this study, we analysed whole blood global gene expression patterns in a worker cohort with altered levels of T cells and immunoglobulins IgM and IgA at three time points; pre-shift, post-shift (after three days), and post-recovery (12 hours later). Eight benzene exposed tank workers performing maintenance work in crude oil cargo tanks with a mean benzene exposure of 0.3 ppm (range 0.1–0.5 ppm) and five referents considered to be unexposed were examined by gene expression arrays. By using our data as independent validation, we reanalysed selected genes that were reported to be altered from previous studies of workers being exposed to sub-ppm benzene levels Four out of six genes previously proposed as marker genes in chronically exposed workers separated benzene exposed workers from unexposed referents (CLEC5, ACSL1, PRG2, IFNB1). Even better separation of benzene exposed workers and referents was observed for short-term exposure for genes in the Jak-STAT pathway, particularly elevated expression of IL6 and reduced expression of IL19.

Suggested Citation

  • Katarina M. Jørgensen & Ellen Færgestad Mosleth & Kristian Hovde Liland & Nancy B. Hopf & Rita Holdhus & Anne-Kristin Stavrum & Bjørn Tore Gjertsen & Jorunn Kirkeleit, 2018. "Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels," IJERPH, MDPI, vol. 15(11), pages 1-18, October.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:11:p:2385-:d:178733
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    References listed on IDEAS

    as
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    3. Hui Zou & Trevor Hastie, 2005. "Addendum: Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(5), pages 768-768, November.
    4. Hui Zou & Trevor Hastie, 2005. "Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(2), pages 301-320, April.
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