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Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol Ester Transfer Protein (CETP) Gene and Dyslipidemia in National Minority Adults in the Far West Region of China

Author

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  • Shuxia Guo

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China
    These authors contributed equally to this work.)

  • Yunhua Hu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China
    These authors contributed equally to this work.)

  • Yusong Ding

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jiaming Liu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Mei Zhang

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Rulin Ma

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Heng Guo

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Kui Wang

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jia He

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Yizhong Yan

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Dongsheng Rui

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Feng Sun

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Lati Mu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Qiang Niu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jingyu Zhang

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Shugang Li

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

Abstract

We have investigated the relationship between the polymorphisms and haplotypes in the CETP gene, and dyslipidemia among the Xinjiang Kazak and Uyghur populations in China. A total of 712 patients with dyslipidemia and 764 control subjects of CETP gene polymorphism at rs12149545, rs3764261, rs1800775, rs711752, rs708272, rs289714, rs5882, and rs1801706 loci were studied by the Snapshot method, linkage disequilibrium analysis and haplotype construction. The results are as follows: (1) the minor allele of eight loci of frequencies in the two groups were different from other results of similar studies in other countries; (2) In the linear regression analysis, the HDL-C levels of rs708272 TT, rs1800775 AA, rs289714 CC and rs711752 AA genotypes were significantly higher than those of other genotypes, however, the rs3764261 GG and rs12149545 GG genotypes were significantly lower than those of other genotypes in the two ethnic groups. The HDL-C levels of the rs12149545 GG genotype were lower than those of other genotypes; (3) in the control group, the rs708272 CT genotype of TG levels were lower than in the CC genotype, the T genotype of LDL-C levels were lower than in the CC genotype, and the HDL-C levels were higher than in the CT genotype; the rs1800775 AC genotype of TG levels were higher than in the AA genotype, the rs711752 AG genotype of TG levels were lower than in the GG genotype, the AA genotype LDL-C levels were lower than in the GG genotype, and the HDL-C levels were higher than in the AG genotype; the rs1800775 AC genotype of TG levels were higher than in the AA genotype. In the dyslipidemia group, the rs708272 TT genotype of TC and LDL-C levels were higher than in the CT genotype and the rs3764261 TT genotype of TC levels were higher than in the GG genotype. The rs711752 AA genotype of TC and LDL-C levels were higher than in the AG genotype, and the rs12149545 AA genotype of TC and LDL-C levels were higher than in the GG genotype; (4) perfect Linkage Disequilibrium was observed for two sets of two SNPs: rs3764261 and rs12149545; rs711752 and rs708272. (5) Using SHEsis software analysis, the five A/T/A/A/T/C/A/G, A/T/A/A/T/T/G/A, G/G/A/G/C/C/G/G, G/G/C/G/C/C/A/G and G/G/C/G/C/T/G/G haplotypes were between dyslipidemia group and control group statistically significantly different ( p < 0.05 in each case). The polymorphism of CETP genes rs708272, rs3764261, rs1800775, rs711752, rs12149545 was closely related to the dyslipidemia in the Xinjiang Uyghur and Kazakh ethnic groups; and the rs708272 T, rs3764261 T, rs711752 A, and rs12149545 A alleles could reduce risk of dyslipidemia in the Uyghur and Kazakh populations, however, the rs1800775 C allele showed risk factors.

Suggested Citation

  • Shuxia Guo & Yunhua Hu & Yusong Ding & Jiaming Liu & Mei Zhang & Rulin Ma & Heng Guo & Kui Wang & Jia He & Yizhong Yan & Dongsheng Rui & Feng Sun & Lati Mu & Qiang Niu & Jingyu Zhang & Shugang Li, 2015. "Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol Ester Transfer Protein (CETP) Gene and Dyslipidemia in National Minority Adults in the Far West Region of China," IJERPH, MDPI, vol. 12(12), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:12:p:15036-15992:d:60725
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    References listed on IDEAS

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    1. David E. Reich & Michele Cargill & Stacey Bolk & James Ireland & Pardis C. Sabeti & Daniel J. Richter & Thomas Lavery & Rose Kouyoumjian & Shelli F. Farhadian & Ryk Ward & Eric S. Lander, 2001. "Linkage disequilibrium in the human genome," Nature, Nature, vol. 411(6834), pages 199-204, May.
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    Cited by:

    1. Jia He & Rulin Ma & Jiaming Liu & Mei Zhang & Yusong Ding & Heng Guo & Lati Mu & Jingyu Zhang & Bin Wei & Yizhong Yan & Jiaolong Ma & Hongrui Pang & Shugang Li & Shuxia Guo, 2017. "The Optimal Ethnic-Specific Waist-Circumference Cut-Off Points of Metabolic Syndrome among Low-Income Rural Uyghur Adults in Far Western China and Implications in Preventive Public Health," IJERPH, MDPI, vol. 14(2), pages 1-12, February.
    2. Ming-hong Yao & Heng Guo & Jia He & Yi-zhong Yan & Ru-lin Ma & Yu-song Ding & Jing-yu Zhang & Jia-ming Liu & Mei Zhang & Shu-gang Li & Shang-zhi Xu & Qiang Niu & Jiao-long Ma & Shu-xia Guo, 2016. "Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China," IJERPH, MDPI, vol. 13(2), pages 1-14, January.
    3. Huixian Hou & Rulin Ma & Heng Guo & Jia He & Yunhua Hu & Lati Mu & Yizhong Yan & Jiaolong Ma & Shugang Li & Jingyu Zhang & Yusong Ding & Mei Zhang & Qiang Niu & Jiaming Liu & Shuxia Guo, 2017. "Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China," IJERPH, MDPI, vol. 14(6), pages 1-14, June.

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