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Food Fortification and Decline in the Prevalence of Neural Tube Defects: Does Public Intervention Reduce the Socioeconomic Gap in Prevalence?

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  • Mohammad M. Agha

    (Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, M5B 1W8, Canada
    Pediatric Oncology Group of Ontario, Toronto, ON M5G 1V2, Canada
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada)

  • Richard H. Glazier

    (Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, M5B 1W8, Canada
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada
    Department of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada)

  • Rahim Moineddin

    (Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, M5B 1W8, Canada
    Department of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada)

  • Aideen M. Moore

    (Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, ON M5T 3M6, Canada
    Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada
    Division of Paediatric Medicine, the Hospital for Sick Children, Toronto, ON M5G 1X8, Canada)

  • Astrid Guttmann

    (Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, ON M5T 3M6, Canada
    Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada
    Division of Paediatric Medicine, the Hospital for Sick Children, Toronto, ON M5G 1X8, Canada)

Abstract

Objective : A significant decline in the prevalence of neural tube defects (NTD) through food fortification has been reported. Questions remain, however, about the effectiveness of this intervention in reducing the gap in prevalence across socioeconomic status (SES). Study Design : Using health number and through record linkage, children born in Ontario hospitals between 1994 and 2009 were followed for the diagnosis of congenital anomalies. SES quintiles were assigned to each child using census information at the time of birth. Adjusted rates and multivariate models were used to compare trends among children born in different SES groups. Results : Children born in low SES areas had significantly higher rates of NTDs (RR = 1.25, CI: 1.14–1.37). Prevalence of NTDs among children born in low and high SES areas declined since food fortification began in 1999 although has started rising again since 2006. While the crude decline was greater in low SES areas, after adjustment for maternal age, the slope of decline and SES gap in prevalence rates remained unchanged overtime. Conclusions : While food fortification is successful in reducing the prevalence of NTDs, it was not associated with removing the gap between high and low SES groups.

Suggested Citation

  • Mohammad M. Agha & Richard H. Glazier & Rahim Moineddin & Aideen M. Moore & Astrid Guttmann, 2013. "Food Fortification and Decline in the Prevalence of Neural Tube Defects: Does Public Intervention Reduce the Socioeconomic Gap in Prevalence?," IJERPH, MDPI, vol. 10(4), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:4:p:1312-1323:d:24646
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    References listed on IDEAS

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    1. Wasserman, C.R. & Shaw, G.M. & Selvin, S. & Gould, J.B. & Syme, S.L., 1998. "Socioeconomic status, neighborhood social conditions, and neural tube defects," American Journal of Public Health, American Public Health Association, vol. 88(11), pages 1674-1680.
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