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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Author

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  • Rosario Nicoletti

    (Council for Agricultural Research and Economics. Rome 00185, Italy
    Department of Agriculture, University Federico II of Naples, Via Università 100, Portici 80055, Italy)

  • Antonio Fiorentino

    (Department of Environmental Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Via Vivaldi 43, Caserta 81100, Italy)

Abstract

It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

Suggested Citation

  • Rosario Nicoletti & Antonio Fiorentino, 2015. "Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta," Agriculture, MDPI, vol. 5(4), pages 1-53, September.
    • Handle: RePEc:gam:jagris:v:5:y:2015:i:4:p:918-970:d:56589
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    References listed on IDEAS

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    1. Charles R. Hipkin & Deborah J. Simpson & Stephen J. Wainwright & Mansour A. Salem, 2004. "Nitrification by plants that also fix nitrogen," Nature, Nature, vol. 430(6995), pages 98-101, July.
    2. Laila P. Partida-Martinez & Christian Hertweck, 2005. "Pathogenic fungus harbours endosymbiotic bacteria for toxin production," Nature, Nature, vol. 437(7060), pages 884-888, October.
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    Cited by:

    1. Gianluca Caruso & Nadezhda Golubkina & Alessio Tallarita & Magdi T. Abdelhamid & Agnieszka Sekara, 2020. "Biodiversity, Ecology, and Secondary Metabolites Production of Endophytic Fungi Associated with Amaryllidaceae Crops," Agriculture, MDPI, vol. 10(11), pages 1-16, November.
    2. Gianluca Caruso & Magdi T. Abdelhamid & Andrzej Kalisz & Agnieszka Sekara, 2020. "Linking Endophytic Fungi to Medicinal Plants Therapeutic Activity. A Case Study on Asteraceae," Agriculture, MDPI, vol. 10(7), pages 1-23, July.
    3. Maria Michela Salvatore & Anna Andolfi & Rosario Nicoletti, 2020. "The Thin Line between Pathogenicity and Endophytism: The Case of Lasiodiplodia theobromae," Agriculture, MDPI, vol. 10(10), pages 1-22, October.
    4. Rosario Nicoletti & Andrea Becchimanzi, 2020. "Endophytism of Lecanicillium and Akanthomyces," Agriculture, MDPI, vol. 10(6), pages 1-16, June.
    5. Rosario Nicoletti, 2019. "Endophytic Fungi of Citrus Plants," Agriculture, MDPI, vol. 9(12), pages 1-13, November.
    6. Rosario Nicoletti, 2020. "Occurrence and Functions of Endophytic Fungi in Crop Species," Agriculture, MDPI, vol. 11(1), pages 1-2, December.
    7. Beata Zimowska & Monika Bielecka & Barbara Abramczyk & Rosario Nicoletti, 2020. "Bioactive Products from Endophytic Fungi of Sages ( Salvia spp.)," Agriculture, MDPI, vol. 10(11), pages 1-16, November.
    8. Maria Michela Salvatore & Artur Alves & Anna Andolfi, 2021. "Secondary Metabolites Produced by Neofusicoccum Species Associated with Plants: A Review," Agriculture, MDPI, vol. 11(2), pages 1-17, February.

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