IDEAS home Printed from
MyIDEAS: Log in (now much improved!) to save this article

Bayesian semiparametric modeling of survival data based on mixtures of B-spline distributions

Listed author(s):
  • Cai, Bo
  • Meyer, Renate
Registered author(s):

    The nonparametric part of a semiparametric regression model usually involves prior specification for an infinite-dimensional parameter F. This paper introduces a class of finite mixture models based on B-spline distributions as an approximation to priors on the set of cumulative distribution functions. This class includes the mixture of beta distributions of Diaconis and Ylvisaker (1985) and the mixtures of triangular distributions of Perron and Mengersen (2001) as special cases. We describe how this approach can be used to model the baseline hazards in a Bayesian stratified proportional hazards model. A numerical illustration is given using survival data from a multicenter clinical AIDS trial, thus generalizing the approach by Carlin and Hodges (1999). Using conditional predictive ordinates and the deviance information criterion, we compare the fit of hierarchical proportional hazards regression models based on mixtures of B-spline distributions of various degrees.

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.

    File URL:
    Download Restriction: Full text for ScienceDirect subscribers only.

    As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

    Article provided by Elsevier in its journal Computational Statistics & Data Analysis.

    Volume (Year): 55 (2011)
    Issue (Month): 3 (March)
    Pages: 1260-1272

    in new window

    Handle: RePEc:eee:csdana:v:55:y:2011:i:3:p:1260-1272
    Contact details of provider: Web page:

    References listed on IDEAS
    Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:

    in new window

    1. Omiros Papaspiliopoulos & Gareth O. Roberts, 2008. "Retrospective Markov chain Monte Carlo methods for Dirichlet process hierarchical models," Biometrika, Biometrika Trust, vol. 95(1), pages 169-186.
    2. F. Perron & K. Mengersen, 2001. "Bayesian Nonparametric Modeling Using Mixtures of Triangular Distributions," Biometrics, The International Biometric Society, vol. 57(2), pages 518-528, 06.
    3. Teh, Yee Whye & Jordan, Michael I. & Beal, Matthew J. & Blei, David M., 2006. "Hierarchical Dirichlet Processes," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 1566-1581, December.
    4. Gelfand, Alan E. & Kottas, Athanasios & MacEachern, Steven N., 2005. "Bayesian Nonparametric Spatial Modeling With Dirichlet Process Mixing," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 1021-1035, September.
    5. Robert, Christian P. & Mengersen, Kerrie L., 1999. "Reparameterisation Issues in Mixture Modelling and their bearing on MCMC algorithms," Computational Statistics & Data Analysis, Elsevier, vol. 29(3), pages 325-343, January.
    6. Bradley P. Carlin & James S. Hodges, 1999. "Hierarchical Proportional Hazards Regression Models for Highly Stratified Data," Biometrics, The International Biometric Society, vol. 55(4), pages 1162-1170, December.
    7. David J. Spiegelhalter & Nicola G. Best & Bradley P. Carlin & Angelika van der Linde, 2002. "Bayesian measures of model complexity and fit," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(4), pages 583-639.
    8. Ruppert,David & Wand,M. P. & Carroll,R. J., 2003. "Semiparametric Regression," Cambridge Books, Cambridge University Press, number 9780521785167, March.
    9. Ruppert,David & Wand,M. P. & Carroll,R. J., 2003. "Semiparametric Regression," Cambridge Books, Cambridge University Press, number 9780521780506, March.
    10. Inyoung Kim & Noah D. Cohen & Raymond J. Carroll, 2003. "Semiparametric Regression Splines in Matched Case-Control Studies," Biometrics, The International Biometric Society, vol. 59(4), pages 1158-1169, December.
    11. Meyer, Renate & Cai, Bo & Perron, Fran├žois, 2008. "Adaptive rejection Metropolis sampling using Lagrange interpolation polynomials of degree 2," Computational Statistics & Data Analysis, Elsevier, vol. 52(7), pages 3408-3423, March.
    Full references (including those not matched with items on IDEAS)

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:55:y:2011:i:3:p:1260-1272. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Dana Niculescu)

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    This information is provided to you by IDEAS at the Research Division of the Federal Reserve Bank of St. Louis using RePEc data.