IDEAS home Printed from https://ideas.repec.org/a/bla/jorssb/v71y2009i1p265-285.html
   My bibliography  Save this article

Empirical Bayes confidence intervals shrinking both means and variances

Author

Listed:
  • J. T. Gene Hwang
  • Jing Qiu
  • Zhigen Zhao

Abstract

Summary. We construct empirical Bayes intervals for a large number p of means. The existing intervals in the literature assume that variances are either equal or unequal but known. When the variances are unequal and unknown, the suggestion is typically to replace them by unbiased estimators . However, when p is large, there would be advantage in ‘borrowing strength’ from each other. We derive double‐shrinkage intervals for means on the basis of our empirical Bayes estimators that shrink both the means and the variances. Analytical and simulation studies and application to a real data set show that, compared with the t‐intervals, our intervals have higher coverage probabilities while yielding shorter lengths on average. The double‐shrinkage intervals are on average shorter than the intervals from shrinking the means alone and are always no longer than the intervals from shrinking the variances alone. Also, the intervals are explicitly defined and can be computed immediately.

Suggested Citation

  • J. T. Gene Hwang & Jing Qiu & Zhigen Zhao, 2009. "Empirical Bayes confidence intervals shrinking both means and variances," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 71(1), pages 265-285, January.
  • Handle: RePEc:bla:jorssb:v:71:y:2009:i:1:p:265-285
    DOI: 10.1111/j.1467-9868.2008.00681.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1467-9868.2008.00681.x
    Download Restriction: no

    File URL: https://libkey.io/10.1111/j.1467-9868.2008.00681.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jing Qiu & J. T. Gene Hwang, 2007. "Sharp Simultaneous Confidence Intervals for the Means of Selected Populations with Application to Microarray Data Analysis," Biometrics, The International Biometric Society, vol. 63(3), pages 767-776, September.
    2. Tong, Tiejun & Wang, Yuedong, 2007. "Optimal Shrinkage Estimation of Variances With Applications to Microarray Data Analysis," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 113-122, March.
    3. Bradley Efron, 2006. "Minimum volume confidence regions for a multivariate normal mean vector," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(4), pages 655-670, September.
    4. Smyth Gordon K, 2004. "Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 3(1), pages 1-28, February.
    5. Richard Samworth, 2005. "Small confidence sets for the mean of a spherically symmetric distribution," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(3), pages 343-361, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yeil Kwon & Zhigen Zhao, 2023. "On F-modelling-based empirical Bayes estimation of variances," Biometrika, Biometrika Trust, vol. 110(1), pages 69-81.
    2. Peter A. Gao & Jonathan Wakefield, 2023. "A Spatial Variance‐Smoothing Area Level Model for Small Area Estimation of Demographic Rates," International Statistical Review, International Statistical Institute, vol. 91(3), pages 493-510, December.
    3. Zhigen Zhao, 2022. "Where to find needles in a haystack?," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 31(1), pages 148-174, March.
    4. Bing-Yi Jing & Zhouping Li & Guangming Pan & Wang Zhou, 2016. "On SURE-Type Double Shrinkage Estimation," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(516), pages 1696-1704, October.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yeil Kwon & Zhigen Zhao, 2023. "On F-modelling-based empirical Bayes estimation of variances," Biometrika, Biometrika Trust, vol. 110(1), pages 69-81.
    2. Dazard, Jean-Eudes & Sunil Rao, J., 2012. "Joint adaptive mean–variance regularization and variance stabilization of high dimensional data," Computational Statistics & Data Analysis, Elsevier, vol. 56(7), pages 2317-2333.
    3. Tong, Tiejun & Jang, Homin & Wang, Yuedong, 2012. "James–Stein type estimators of variances," Journal of Multivariate Analysis, Elsevier, vol. 107(C), pages 232-243.
    4. Xiao Min & Chen Ting & Ming Ruixing & Huang Kunpeng, 2020. "Optimal Estimation for Power of Variance with Application to Gene-Set Testing," Journal of Systems Science and Information, De Gruyter, vol. 8(6), pages 549-564, December.
    5. Ji Tieming & Liu Peng & Nettleton Dan, 2012. "Borrowing Information Across Genes and Experiments for Improved Error Variance Estimation in Microarray Data Analysis," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(3), pages 1-29, May.
    6. Qiu Jing & Qi Yue & Cui Xiangqin, 2014. "Applying shrinkage variance estimators to the TOST test in high dimensional settings," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 13(3), pages 1-19, June.
    7. Bedbur, S. & Lennartz, J.M. & Kamps, U., 2020. "On minimum volume properties of some confidence regions for multiple multivariate normal means," Statistics & Probability Letters, Elsevier, vol. 158(C).
    8. Aaron C Ericsson & J Wade Davis & William Spollen & Nathan Bivens & Scott Givan & Catherine E Hagan & Mark McIntosh & Craig L Franklin, 2015. "Effects of Vendor and Genetic Background on the Composition of the Fecal Microbiota of Inbred Mice," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-19, February.
    9. Hossain, Ahmed & Beyene, Joseph & Willan, Andrew R. & Hu, Pingzhao, 2009. "A flexible approximate likelihood ratio test for detecting differential expression in microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 53(10), pages 3685-3695, August.
    10. Xiaohong Li & Guy N Brock & Eric C Rouchka & Nigel G F Cooper & Dongfeng Wu & Timothy E O’Toole & Ryan S Gill & Abdallah M Eteleeb & Liz O’Brien & Shesh N Rai, 2017. "A comparison of per sample global scaling and per gene normalization methods for differential expression analysis of RNA-seq data," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-22, May.
    11. Kerr Kathleen F., 2012. "Optimality Criteria for the Design of 2-Color Microarray Studies," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(1), pages 1-9, January.
    12. Ambroise Jérôme & Bearzatto Bertrand & Robert Annie & Macq Benoit & Gala Jean-Luc, 2012. "Combining Multiple Laser Scans of Spotted Microarrays by Means of a Two-Way ANOVA Model," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(3), pages 1-20, February.
    13. J. McClatchy & R. Strogantsev & E. Wolfe & H. Y. Lin & M. Mohammadhosseini & B. A. Davis & C. Eden & D. Goldman & W. H. Fleming & P. Conley & G. Wu & L. Cimmino & H. Mohammed & A. Agarwal, 2023. "Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    14. Bing-Yi Jing & Zhouping Li & Guangming Pan & Wang Zhou, 2016. "On SURE-Type Double Shrinkage Estimation," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(516), pages 1696-1704, October.
    15. Alexandra Gyurdieva & Stefan Zajic & Ya-Fang Chang & E. Andres Houseman & Shan Zhong & Jaegil Kim & Michael Nathenson & Thomas Faitg & Mary Woessner & David C. Turner & Aisha N. Hasan & John Glod & Ro, 2022. "Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    16. Sora Yoon & Seon-Young Kim & Dougu Nam, 2016. "Improving Gene-Set Enrichment Analysis of RNA-Seq Data with Small Replicates," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-16, November.
    17. Yu Lianbo & Gulati Parul & Fernandez Soledad & Pennell Michael & Kirschner Lawrence & Jarjoura David, 2011. "Fully Moderated T-statistic for Small Sample Size Gene Expression Arrays," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 10(1), pages 1-22, September.
    18. Chaofeng Yuan & Wensheng Zhu & Xuming He & Jianhua Guo, 2019. "A mixture factor model with applications to microarray data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 28(1), pages 60-76, March.
    19. Nan Li & Matthew N. McCall & Zhijin Wu, 2017. "Establishing Informative Prior for Gene Expression Variance from Public Databases," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 9(1), pages 160-177, June.
    20. Brian Caffo & Liu Dongmei & Giovanni Parmigiani, 2004. "Power Conjugate Multilevel Models with Applications to Genomics," Johns Hopkins University Dept. of Biostatistics Working Paper Series 1062, Berkeley Electronic Press.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bla:jorssb:v:71:y:2009:i:1:p:265-285. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://edirc.repec.org/data/rssssea.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.