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Using Joint Utilities of the Times to Response and Toxicity to Adaptively Optimize Schedule–Dose Regimes

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  • Peter F. Thall
  • Hoang Q. Nguyen
  • Thomas M. Braun
  • Muzaffar H. Qazilbash

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  • Peter F. Thall & Hoang Q. Nguyen & Thomas M. Braun & Muzaffar H. Qazilbash, 2013. "Using Joint Utilities of the Times to Response and Toxicity to Adaptively Optimize Schedule–Dose Regimes," Biometrics, The International Biometric Society, vol. 69(3), pages 673-682, September.
    • Handle: RePEc:bla:biomet:v:69:y:2013:i:3:p:673-682
    DOI: 10.1111/biom.12065
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    References listed on IDEAS

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    1. Peter F. Thall & Aniko Szabo & Hoang Q. Nguyen & Catherine M. Amlie-Lefond & Osama O. Zaidat, 2011. "Optimizing the Concentration and Bolus of a Drug Delivered by Continuous Infusion," Biometrics, The International Biometric Society, vol. 67(4), pages 1638-1646, December.
    2. Peter F. Thall & John D. Cook, 2004. "Dose-Finding Based on Efficacy–Toxicity Trade-Offs," Biometrics, The International Biometric Society, vol. 60(3), pages 684-693, September.
    3. Ying Kuen Cheung & Rick Chappell, 2000. "Sequential Designs for Phase I Clinical Trials with Late-Onset Toxicities," Biometrics, The International Biometric Society, vol. 56(4), pages 1177-1182, December.
    4. Ying Yuan & Guosheng Yin, 2009. "Bayesian dose finding by jointly modelling toxicity and efficacy as time‐to‐event outcomes," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 58(5), pages 719-736, December.
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    Cited by:

    1. Emma Gerard & Sarah Zohar & Hoai‐Thu Thai & Christelle Lorenzato & Marie‐Karelle Riviere & Moreno Ursino, 2022. "Bayesian dose regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics," Biometrics, The International Biometric Society, vol. 78(1), pages 300-312, March.
    2. Peter F. Thall & Hoang Q. Nguyen & Ralph G. Zinner, 2017. "Parametric dose standardization for optimizing two-agent combinations in a phase I–II trial with ordinal outcomes," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(1), pages 201-224, January.
    3. Thomas A. Murray & Peter F. Thall & Ying Yuan & Sarah McAvoy & Daniel R. Gomez, 2017. "Robust Treatment Comparison Based on Utilities of Semi-Competing Risks in Non-Small-Cell Lung Cancer," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(517), pages 11-23, January.

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