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Implementation of a Bayesian Design in a Dose-Escalation Study of an Experimental Agent in Healthy Volunteers

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  • Yinghui Zhou
  • John Whitehead
  • Pasi Korhonen
  • Mika Mustonen

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  • Yinghui Zhou & John Whitehead & Pasi Korhonen & Mika Mustonen, 2008. "Implementation of a Bayesian Design in a Dose-Escalation Study of an Experimental Agent in Healthy Volunteers," Biometrics, The International Biometric Society, vol. 64(1), pages 299-308, March.
  • Handle: RePEc:bla:biomet:v:64:y:2008:i:1:p:299-308
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    File URL: http://hdl.handle.net/10.1111/j.1541-0420.2007.00841.x
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    References listed on IDEAS

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    1. B. Nebiyou Bekele & Yu Shen, 2005. "A Bayesian Approach to Jointly Modeling Toxicity and Biomarker Expression in a Phase I/II Dose-Finding Trial," Biometrics, The International Biometric Society, vol. 61(2), pages 343-354, June.
    2. Anastasia Ivanova, 2003. "A New Dose-Finding Design for Bivariate Outcomes," Biometrics, The International Biometric Society, vol. 59(4), pages 1001-1007, December.
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    Cited by:

    1. Alam, M. Iftakhar & Bogacka, Barbara & Coad, D. Stephen, 2017. "Pharmacokinetically guided optimum adaptive dose selection in early phase clinical trials," Computational Statistics & Data Analysis, Elsevier, vol. 111(C), pages 183-202.

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