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Effects of Fractionated Methanolic Leaf Extract of Gongronema latifoliumon CCl4-induced Wistar Albino Rats

Author

Listed:
  • Okpala Jude Chinedu
  • Sani Ibrahim
  • Nzelibe Henry Chukwuemeka

    (Department of Biochemistry, Ahmadu Bello University, Nigeria)

  • Akpa Alex Uwadiegwu

    (Department of Medical Biotechnology, National Biotechnology Development Agency, Nigeria)

Abstract

The general aim of this study is to assess the effects of fractionated methanolic leaf extract of Gongronema latifoliumon CCl4-induced wistar albino rats. Fifty-four (54) Wistar albino rats were divided into seven treatment groups. Group A was given feed and water, Group B was injected with olive oil intra peritoneally, while the rest of the groups (C, D, E, F and G) were injected intra peritoneally with a single dose of CCl4 (148 mg/kg). After 36 hours of induction, group E, F and G were given 100 mg/kg, 150 mg/kg and 200 mg/kg body weight of n-butanol fraction of methanol leaf extract of Gongronema latifolium by oral gavage. Group D was given 100 mg/kg of silymarin (standard drug) whereas group C served as CCl4 -induced group. At the end of 28 days of treatment, there were significant (P

Suggested Citation

  • Okpala Jude Chinedu & Sani Ibrahim & Nzelibe Henry Chukwuemeka & Akpa Alex Uwadiegwu, 2015. "Effects of Fractionated Methanolic Leaf Extract of Gongronema latifoliumon CCl4-induced Wistar Albino Rats," Journal of Pharmacology & Clinical Research, Juniper Publishers Inc., vol. 1(1), pages 1-18, April.
    • Handle: RePEc:adp:oajpcr:v:1:y:2015:i:1:p:1-18
    DOI: 10.19080/JPCR.2015.01.555551
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