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Calcified Large Arteries, Osteoporosis & Acute Stroke What is the Relationship

Author

Listed:
  • Hesham Hamoud
  • Abdulaziz A. Mustafa

    (Rheumatology, Al-Azhar University, Egypt)

  • Husein Mohamad

    (Neurology & Clinical Pathology Departments, Al-Azhar University, Egypt)

  • Gamal El kheshen

    (Clinical pathology Departments, Al-Azhar University, Egypt)

Abstract

Atherosclerosis and osteoporosis are currently considered unrelated diseases. As age advances, osteoporosis is more frequently found in women than men; atherosclerosis is an illness predominantly affecting men [1]. A parallel relationship has been noted between spinal osteoporosis and aortic calcification due to atherosclerosis [2]. Osteoporosis and stroke share several risk factors, such as age, smoking, low level of physical activity, and hypertension [3]. Thus Low bone mineral density (BMD) and a high risk of stroke may thus be related, but studies on this relationship are sparse. Both bone and atherosclerotic arteries contain osteopontin, matrix gla protein, bone morphogenetic protein collagen I, osteonectin, Osteocalcin, nitric oxide, and matrix vesicles [4]. Atherosclerosis and osteoporosis both involve recruitment and differentiation of monocytic cells that differentiate into macrophage-foam cells in artery and osteoclasts in bone [5]. The artery wall contains cells capable of differentiation into osteoblasts, following the same stages of differentiation as occur in bone-derived osteoblasts, and ultimately producing bone mineral [6].

Suggested Citation

  • Hesham Hamoud & Abdulaziz A. Mustafa & Husein Mohamad & Gamal El kheshen, 2017. "Calcified Large Arteries, Osteoporosis & Acute Stroke What is the Relationship," Orthopedics and Rheumatology Open Access Journals, Juniper Publishers Inc., vol. 6(1), pages 32-38, April.
    • Handle: RePEc:adp:joroaj:v:6:y:2017:i:1:p:32-38
    DOI: 10.19080/OROAJ.2017.06.555685
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