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Intradiscal Injection of an Autologous Alpha-2-Macroglobulin (A2M) Concentrate Alleviates Back Pain in FAC-Positive Patients

Author

Listed:
  • Pasquale X Montesano MD

    (Spine Surgeon, Montesano Spine and Sport, USA)

  • Jason M Cuellar MD

    (Spine surgeon, Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, USA)

  • PhD, Gaetano J Scuderi MD

    (Spine surgeon, USA)

Abstract

Objectives: A cartilage degradation product, the Fibronectin-Aggrecan complex (FAC), has been identified in patients with degenerative disc disease (DDD). Alpha-2-macroglobulin (A2M) can prevent the formation of the G3 domain of aggrecan, reducing the fibronectin-aggrecan G3 complex and therefore may be an efficacious treatment. The present study was designed to determine a. The ability of autologous concentrated A2M to relieve back pain in patients with LBP from DDD and b. The ability of FAC to predict the response to this biologic therapy

Suggested Citation

  • Pasquale X Montesano MD & Jason M Cuellar MD & PhD, Gaetano J Scuderi MD, 2017. "Intradiscal Injection of an Autologous Alpha-2-Macroglobulin (A2M) Concentrate Alleviates Back Pain in FAC-Positive Patients," Orthopedics and Rheumatology Open Access Journals, Juniper Publishers Inc., vol. 4(1), pages 42-46, January.
    • Handle: RePEc:adp:joroaj:v:4:y:2017:i:1:p:42-46
    DOI: 10.19080/OROAJ.2017.04.555634
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