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Metabolic Comorbidities in Rheumatic Diseases

Author

Listed:
  • V Pucino

    (William Harvey Research Institute Barts and The London SMD Queen Mary, University of London, UK)

  • G Marone
  • A De Paulis

    (Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), World Allergy Organization (WAO) Center of Excellence, University of Naples Federico II, Naples, Italy)

Abstract

Patients with rheumatic diseases (RD) are at high risk of developing several comorbid conditions, including cardiovascular diseases (CVD) and metabolic syndrome (MetS) compared to healthy population. These events have a great effect on mortality [1,2]. The pathogenic factors involved are not yet fully understood. Metabolic syndrome (MetS), which includes insulin resistance, central obesity, dyslipidemia, and hypertension, may provide a link between accelerated atherosclerosis and inflammation in these diseases. Oxidative stress markers, thrombogenic or pro-inflammatory mediators released in course of autoimmune rheumatic diseases play a key role in the development in atherosclerosis, or other cardiometabolic disturbances frequently observed in these patients [1,2].

Suggested Citation

  • V Pucino & G Marone & A De Paulis, 2018. "Metabolic Comorbidities in Rheumatic Diseases," Orthopedics and Rheumatology Open Access Journals, Juniper Publishers Inc., vol. 13(2), pages 33-34, October.
    • Handle: RePEc:adp:joroaj:v:13:y:2018:i:2:p:33-34
    DOI: 10.19080/OROAJ.2018.13.555857
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