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Influence of Donor and Acceptor Substituents in 1,3-Oxazole Derivatives and their Anti-Cancer Activity

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  • Nataliya V Obernikhina

    (Department of Bioorganic and Biological Chemistry, O.O. Bogomolets National Medical University, Ukraine)

Abstract

The heterocyclic compounds with branched conjugated systems including oxazole, thiazole or pirazole moieties have shown themselves as powerful scaffold in drug design, especially, highly active anticancer agents [1]. Consequently, the 1,3-oxazole skeleton could regard as applicable biologically active fragment. This molecular moiety can generate the enough “rigid†structure with the many biopolymers, what is considered as an important condition for increasing of selectivity to potential targets.

Suggested Citation

  • Nataliya V Obernikhina, 2019. "Influence of Donor and Acceptor Substituents in 1,3-Oxazole Derivatives and their Anti-Cancer Activity," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 9(1), pages 1-6, September.
  • Handle: RePEc:adp:jomcij:v:9:y:2019:i:1:p:1-6
    DOI: 10.19080/OMCIJ.2019.09.555751
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