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Synthesis and Cytotoxicity Evaluation of Some New 4-(4oxo-4H-Quinazoline-3yl)- Thiobenzoic Acid-S-(1-H-Benzimidazole-2-Yl) Ester Derivates

Author

Listed:
  • Shirin Banitalebi Dehkordi
  • Farshid Hassanzadeh

    (Department of Medicinal Chemistry, Isfahan University of Medical Sciences, Iran)

  • Marzieh Rahmani Khajouei
  • Hojat Sadeghi

    (Isfahan Pharmaceutical Sciences Research Center, Isfahan, Iran)

  • Nasim Dana

    (Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran)

Abstract

Quinazolines are a group of heterocyclic compounds that have different biological activities such as cytotoxicity, anti-bacterial, anti-fungal. benzimidazoles on the other hand are also a group of heterocyclic compounds with anti-tumor, anti-virus, anti-fungal and anti-inflammatory effects. Due to significant cytotoxic effects of both quinazoline and benzimidazole derivatives , in this work a group of quinazolinone-benzimidazole hybrids were prepared. The structures of synthesized compounds were confirmed by IR and 1H-NMR. Cytotoxic activity of the compounds was evaluated at 1, 10, and 100 μM concentrations against MCF-7 and HT-29 cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. The results show that compound 9d has highest cytotoxic activity against both MCF-7 and HT-29 cell lines.

Suggested Citation

  • Shirin Banitalebi Dehkordi & Farshid Hassanzadeh & Marzieh Rahmani Khajouei & Hojat Sadeghi & Nasim Dana, 2019. "Synthesis and Cytotoxicity Evaluation of Some New 4-(4oxo-4H-Quinazoline-3yl)- Thiobenzoic Acid-S-(1-H-Benzimidazole-2-Yl) Ester Derivates," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 8(5), pages 133-138, September.
    • Handle: RePEc:adp:jomcij:v:8:y:2019:i:5:p:133-138
    DOI: 10.19080/OMCIJ.2019.08.555750
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