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Isolation and Microbial Screening of 1-Methylcyclopentene from Bracystelma Togoense Schtlr

Author

Listed:
  • Abiche Ekalu

    (Nigerian Army School of Education, Nigeria)

  • Rachael Gbekele-Oluwa Ayo
  • James D Habila
  • Ibrahim Hamisu

    (Ahmadu Bello University Zaria, Kaduna, Nigeria)

Abstract

The secondary metabolites, 1-methylcyclopentene was isolated from the CH2Cl2 extract of Brachystelma togoense used traditionally for treatment of ailments. The structure was elucidated using 1H, 13C and 2D NMR. 1-methylcyclopentene previously undescribed from plant sources had shown various biological activities S. aureus, E. coli, S. pneumonia, S. typhi, and C. albicans. It was observed that 1-methylcyclopentene was more active against C. albicans (24mm) and E. coli (20mm). 1-methylcyclopentene also showed the highest activity against E. coli (0.1875 mg/mL) and C. albicans (0.1875 mg/mL). The MBC/MFC was observed for E. coli (0.75 mg/mL), S. pneumonia (0.75 mg/mL), S. typhi (0.75 mg/mL) and C. albicans (0.375 mg/mL) respectively. The activity of 1-methylcyclopentene in B. togoense justified ethnomedicinal uses of the plant.

Suggested Citation

  • Abiche Ekalu & Rachael Gbekele-Oluwa Ayo & James D Habila & Ibrahim Hamisu, 2019. "Isolation and Microbial Screening of 1-Methylcyclopentene from Bracystelma Togoense Schtlr," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 8(3), pages 78-85, May.
    • Handle: RePEc:adp:jomcij:v:8:y:2019:i:3:p:78-85
    DOI: 10.19080/OMCIJ.2019.08.555740
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