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NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor) Drug AZT and Their Preparation & Determination A Patent Evaluation of Efavirenz

Author

Listed:
  • Krishna sarmapathy

    (Department of Organic Chemistry, Head IPL research Centre, India)

Abstract

Human immunodeficiency virus type-1 (HIV-1) is the causative agent for the transmission and development of the acquired immunodeficiency syndrome (AIDS).Efavirenz (II) a potent NNRTI, is a significant component of a very effective (protease sparing) regimen when co administered with AZT and 3TC [1]. Importance of Efavirenz led to the development of several strategies for its synthesis, and preparation was described in this paper, the world great potential drug Efavirenz still inaccessible to millions of people because of its atom economy and toxic [2]. Patent evaluation on process patents and well defined summary of patents . During the course of drug development most of the world pharmaceutical companies attempt well in the handling of environment friendly Efavirenz development especially Merck. We have surprisingly found that compound of Efavirenz can be prepared in good yield and high purity by Cyclisation of compound of (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol with urea. Finally, Analytical method for determination Efavirenz has the absorbance maxima at 561 nm for the first order derivative visible-Spectrophotometric method.

Suggested Citation

  • Krishna sarmapathy, 2019. "NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor) Drug AZT and Their Preparation & Determination A Patent Evaluation of Efavirenz," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 8(3), pages 68-77, May.
    • Handle: RePEc:adp:jomcij:v:8:y:2019:i:3:p:68-77
    DOI: 10.19080/OMCIJ.2019.08.555739
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