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Design and Synthesis of Antifungal Compounds from 1,2,3-Triazoles through the Click Chemistry Approach

Author

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  • Ana Karla Estrada Valdés
  • Erick Cuevas-Yañez

    (Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Mexico)

Abstract

1,2,3-triazoles are easily prepared from CuAAC reaction and represent a potential source of antifungal compounds analogous to azole drugs. Accordingly, research groups have synthesized diverse 1,2,3-triazoles with modulated antifungal activity through the substituents in azide or alkyne precursors. A brief review of the state of the art about this topic is presented, focusing the increasing importance of developing new and more selective antifungal compounds.

Suggested Citation

  • Ana Karla Estrada Valdés & Erick Cuevas-Yañez, 2019. "Design and Synthesis of Antifungal Compounds from 1,2,3-Triazoles through the Click Chemistry Approach," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 8(2), pages 43-45, March.
    • Handle: RePEc:adp:jomcij:v:8:y:2019:i:2:p:43-45
    DOI: 10.19080/OMCIJ.2019.08.555734
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