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Synthesis of Substituted Quinazolines Containing Pharmacophoric Groups

Author

Listed:
  • Harutyunyan Artur A
  • Ghukasyan Gohar T

    (Russian Armenian (Slavonic) University, Armenia, Europa)

  • Danagulyan Gevorg G

    (Scientific and technological center of organic and pharmaceutical chemistry, Armenia)

Abstract

Continuing research on the synthesis of biologically active quinazoline derivatives [1,2] in this report we have described the synthesis of previously unknown substituted 2-methylquin-zolins and 2-[2-aryl(hetaryl)vinyl]quinazolines, which contain pharmacophore groups at different positions of the ring. Synthesis was carried out by the interaction of 2-methyl-4H-3,1-benzoxzin-4-ones 1a, b with aromatic and heterocyclic amines, according to the Scheme 1.

Suggested Citation

  • Harutyunyan Artur A & Ghukasyan Gohar T & Danagulyan Gevorg G, 2018. "Synthesis of Substituted Quinazolines Containing Pharmacophoric Groups," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 8(1), pages 15-16, October.
  • Handle: RePEc:adp:jomcij:v:8:y:2018:i:1:p:15-16
    DOI: 10.19080/OMCIJ.2018.08.555729
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