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Entecavir Patent Evaluation, Method for Diastereomeric Impurities

Author

Listed:
  • Krishna Sarma Pathy

    (Head –QC,QA/R&D-IPL Research Centre Lucknow, India)

Abstract

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, The initial patent on entecavir expired in South Africa in 2011 ZA 1991/07894. Current status available on: http://patentsearch.cipc.co.za/, which should have permitted lower-cost generic competitors to enter the market. However, South Africa granted BMS three additional patents on entecavir that only expire between 2022 and 2026. Two of these patents have lapsed-meaning BMS has not paid the renewal fees, and they cannot be enforced-while one patent covering a lower dosage form of entecavir remains in force.

Suggested Citation

  • Krishna Sarma Pathy, 2018. "Entecavir Patent Evaluation, Method for Diastereomeric Impurities," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 7(3), pages 83-96, June.
    • Handle: RePEc:adp:jomcij:v:7:y:2018:i:3:p:83-96
    DOI: 10.19080/OMCIJ.2018.07.555711
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