Quinoline-Substituted 1,2,3-Triazole-Based Molecules, As Promising Conjugated Hybrids in Biomedical Research

Building a single molecular framework containing quinoline and triazoles rings of promising biological activity through molecular hybridization strategy offers the viewpoint of better drugs for the treatment of a number of diseases including cancer, malaria, tuberculosis and other illnesses. Presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects, these molecular hybrids are gaining momentum worldwide showing their promise in drug discovery. Such hybrid molecules are usually made efficiently through click chemistry technique using multicomponent reactions. In this paper, we discuss chemistry and biology of some quinoline-substituted 1,2,3-triazole hybrids aiming at a better understanding of physicochemical properties of quinoline-triazole hybrids for designing novel bioactive chemical entities. So, principal Lipinski’ parameters and in silico study (lipophilicity and molecular polar surface area) are also briefly mentioned and applied to selected quinoline-1,2,3-triazole hybrids. The mini-review is divided in two general parts: synthetic aspects of the preparation of these hybrids and their pharmacological aspects paying attention to the widespread dangerous diseases such as malaria, cancer, and human fungal infections, especially systemic mycoses.