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Route Evaluation and Analytical HPLC Method Development of Buprenorphine, Naloxone, and Comparison Overall Efficiency of Naltrexone Nalbuphine Traces The Evolution of Various Approaches

Author

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  • Krishna Sarma Pathy

    (Head, QC,QA/R&D-IPL Research Centre Lucknow, India)

Abstract

This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatographic (RP¬HPLC) method has been developed and validated for simultaneous estimation of Naloxone Hydrochloride and Buprenorphine Hydrochloride in pure and marketed formulations.

Suggested Citation

  • Krishna Sarma Pathy, 2018. "Route Evaluation and Analytical HPLC Method Development of Buprenorphine, Naloxone, and Comparison Overall Efficiency of Naltrexone Nalbuphine Traces The Evolution of Various Approaches," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 7(2), pages 36-57, June.
    • Handle: RePEc:adp:jomcij:v:7:y:2018:i:2:p:36-57
    DOI: 10.19080/OMCIJ.2018.07.555706
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