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Synthesis of Some N-Alkyl and N-Aryl Amides as Potential Central Nervous System-Active Anticonvulsant Agents

Author

Listed:
  • Afolabi O Ezekiel
  • Agwom M Francis

    (Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria)

  • Kindala T Junior
  • Bot J Kim

    (Department of Chemistry, Faculty of Sciences, University of Kinshasa, DR Congo)

Abstract

Epilepsy affects about 0.5 to 1% of the world’s population. The perfect anti-epileptic drug is as yet unavailable. A carefully balance between toxicity site of most available anti-epileptic agent and their seizure activity are mostly done before uses. New and safe anticonvulsant drugs are urgently needed. Most drugs in current usage have developed based on optimization of lead compounds, either isolated from the screening of natural products, or modified from hormone or transmitter whose activity is being studied

Suggested Citation

  • Afolabi O Ezekiel & Agwom M Francis & Kindala T Junior & Bot J Kim, 2018. "Synthesis of Some N-Alkyl and N-Aryl Amides as Potential Central Nervous System-Active Anticonvulsant Agents," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 6(3), pages 60-68, April.
    • Handle: RePEc:adp:jomcij:v:6:y:2018:i:3:p:60-68
    DOI: 10.19080/OMCIJ.2018.06.555688
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