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Correction: Association between Technology Development and Rounder Substituted-1h-Indole-2, 3-Dione Hiv-1 Inhibitors Who Have Displays Strategic Nanomolar Cytotoxicity

Author

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  • Ramesh Paranjape

    (National AIDS Research Institute, India)

  • Rahul Hajare

    (Indian Council of Medical Research, Vinayaka Mission University, India)

Abstract

Model speeds drug discovery a series of novel, twenty 1,3,5-tri substituted-1H- indole 2,3-dione scaffold on a putative „U shape‟ molecular recognition of novel HIV-1 inhibitors were designed and synthesized using a parallel synthesis unit processes technology. Among synthesized and tested compounds 1A, 1B, 1C, 1D, 1E, 1F, 1G and 1H found good quality of IC50 ranges from 4.91 to 32.01μg. One among those, compound 1C is the most potent inhibitor as a target compound against HIV-1. Target compound N-[(3Z) 5-methoxy-1-(morpholin-4-ylmethyl)-2-oxo-1,2-dihydro-3H-indol-3ylidene]amino}benzene sulfamethaxazole (1C) tactically very low cytotoxicity (CC50>1mM). It is reported 7.15 μg/ml to engineered cell lines, TZM- l (JC53BL-13).

Suggested Citation

  • Ramesh Paranjape & Rahul Hajare, 2018. "Correction: Association between Technology Development and Rounder Substituted-1h-Indole-2, 3-Dione Hiv-1 Inhibitors Who Have Displays Strategic Nanomolar Cytotoxicity," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 6(3), pages 50-53, April.
    • Handle: RePEc:adp:jomcij:v:6:y:2018:i:3:p:50-53
    DOI: 10.19080/OMCIJ.2018.06.555686
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