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Alkylation of N,N-dimethylethanolamine with Benzhydryl Halogenide in PTC Condition

Author

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  • GH Torosyan

    (National polytechnic university of Armenia, Yerevan)

Abstract

The direct O- alkylation of dimethylethanolamine (DMEA) by benzhydryl chloride (BhHlg) as electrophilic reagent was performed in Phase Transfer Catalysis system (PTC). It was presented the possibilities for best yield of O-alkylated product - Diphenhydramine in PTC process. The hydrochloride of obtained amino-ether is a widely known drug – dimedrol.

Suggested Citation

  • GH Torosyan, 2018. "Alkylation of N,N-dimethylethanolamine with Benzhydryl Halogenide in PTC Condition," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 6(2), pages 44-45, April.
    • Handle: RePEc:adp:jomcij:v:6:y:2018:i:2:p:44-45
    DOI: 10.19080/OMCIJ.2018.06.555684
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