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Preparation of Novel Morphinan Derivative as a Result of Grewe Cyclization

Author

Listed:
  • Sureshbabu Jayachandra
  • Madhuresh Kumar Sethi
  • Sanjay Mahajan
  • Bhairaiah Mara
  • Gurleen Kaur
  • Ruchira Sarbajana
  • Chandan Vydana
  • Vittal Bhattu
  • Purbita Chakraborty

    (R & D Mylan Laboratories Ltd, ANRICH Industrial Estate, India)

Abstract

The acid catalyzed cyclization of Benzyl substituted Octahydroisoquinoline results in the formation of a major product, N-Formyl Dextromethorphan and a minor product, one of the morphinan derivatives, which is formed via the mechanism of Super electrophiles. Excess Phosphoric acid acts as an electrophile and leads to the formation of a novel minor product but has a significant existence and can be isolated using Column Chromatography at the later stages.

Suggested Citation

  • Sureshbabu Jayachandra & Madhuresh Kumar Sethi & Sanjay Mahajan & Bhairaiah Mara & Gurleen Kaur & Ruchira Sarbajana & Chandan Vydana & Vittal Bhattu & Purbita Chakraborty, 2018. "Preparation of Novel Morphinan Derivative as a Result of Grewe Cyclization," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 6(1), pages 17-22, March.
    • Handle: RePEc:adp:jomcij:v:6:y:2018:i:1:p:17-22
    DOI: 10.19080/OMCIJ.2018.06.555678
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