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Simultaneous Estimation of Aliskiren and Amlodipine in Combined Tablet Formulation by Simultaneous Equation and First Derivative Spectroscopic Methods

Author

Listed:
  • Yadav N

    (Department of Pharmacy, SRMSCET, India)

  • Goyal A

    (B N Institute of Pharmaceutical Sciences, India)

Abstract

Simple, sensitive and accurate UV-spectroscopic methods were developed and validated for simultaneous estimation of aliskiren and amlodipine in tablet formulation using simultaneous equation and first derivative spectroscopic methods. Developed methods include direct estimation of amlodipine at 365nm without any interference, since aliskiren has zero absorbance at this wavelength. Estimation of aliskiren through simultaneous equation was performed at 279 nm, while 236.8 nm were selected as zero crossing point for estimation of aliskiren by first order derivative spectroscopic method. Linearity was found to be satisfactory over the concentration range of 25-300μg/ml and 5-100μg/ml for aliskiren and amlodipine respectively. The mean percentage label claim of aliskiren and amlodipine using simultaneous equation was 99.84 and 99.85 % respectively, while for first derivative spectroscopic method it was found to be 100.36 and 99.85% respectively. The developed methods are economical and reproducible for routine analysis of aliskiren and amlodipine in tablet formulation.

Suggested Citation

  • Yadav N & Goyal A, 2018. "Simultaneous Estimation of Aliskiren and Amlodipine in Combined Tablet Formulation by Simultaneous Equation and First Derivative Spectroscopic Methods," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 6(1), pages 1-5, March.
    • Handle: RePEc:adp:jomcij:v:6:y:2018:i:1:p:1-5
    DOI: 10.19080/OMCIJ.2018.06.555676
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