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Water Pollution

Author

Listed:
  • Evelyn U Godwin Nwakwasi

    (Department of Chemistry, Gregory University Uturu Abia State, Nigeria)

  • Uchechukwu C Okoro
  • Mercy A Ezeokonkwo

    (Department of Pure and Industrial Chemistry, University of Nigeria Nsukka, Nigeria)

  • Fidelia N Ibeanu

    (School of General Studies, Natural Science Unit, University of Nigeria Nsukka, Nigeria)

  • Ifeoma C Ugwu

    (Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Nigeria)

Abstract

In a continued search for new biologically active angular phenothiazine compounds, novel non-linear polycyclic phenothiazine halogeno derivatives have been synthesized via coupling reactions. The coupling of equimolar mixture of 2-amino-5-bromopyrazine-3[4H]-thione and 6,7-dibromo-5,8-quninolinequinone under anhydrous condition, furnished two isomers, 6,9-dibromo-1, 8, 11-traiza-5H-benzo[a]phenothiazin-5-one and 6,9-dibromo-4, 8, 11-triaza-5H-benzo[a]phenothiazin-5-one. These compounds were screened for their antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations using Agar-well diffusion method and the results showed that these phenothiazine moieties had significant biological activity and inhibited the growth of these bacterial isolates even at low concentrations. Structures were assigned based on spectroscopic data and elemental analysis.

Suggested Citation

  • Evelyn U Godwin Nwakwasi & Uchechukwu C Okoro & Mercy A Ezeokonkwo & Fidelia N Ibeanu & Ifeoma C Ugwu, 2018. "Water Pollution," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 5(4), pages 101-106, February.
    • Handle: RePEc:adp:jomcij:v:5:y:2018:i:4:p:101-106
    DOI: 10.19080/OMCIJ.2018.05.555666
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