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Synthesis, Characterization, Thermodynamic and Biological Activity Studies for New Complexes of Some Transition Metals and Zinc With Schiff’s Bases [2,5di (1-Thi-Ophen-2-yl-Ethylidene)-Hydrazine) 1, 3, 4-Thiadiazole]

Author

Listed:
  • Cesar A C Sequeira

    (Center of Physics and Engineering of Advanced Materials, Instituto Superior Técnico, University of Lisbon, Portugal)

Abstract

Because of their magnetic and superparamagnetic properties, iron oxide nanoparticles (IONPs) have many potential applications for medical use. The synthesis of these nanoparticles (NPs) has been the basis of many studies, each proposing different synthesis methods yielding nanostructures of different properties. In this review the synthesis of biologically compatible IONPs by electrochemical deposition is described, thus exploring their potential use in biomedical applications. The chemical, physical and magnetic properties of these nanostructures are examined to determine their possible application in magnetic resonance imaging (MRI) contrast enhancement and thermal activation therapy. NPs characterization and demonstration of their potential uses pave the way to the development of smart magnetic IONPs for targeted diagnostics and therapeutics of human diseases, including cancer and Alzheimer’s disease.

Suggested Citation

  • Cesar A C Sequeira, 2018. "Synthesis, Characterization, Thermodynamic and Biological Activity Studies for New Complexes of Some Transition Metals and Zinc With Schiff’s Bases [2,5di (1-Thi-Ophen-2-yl-Ethylidene)-Hydrazine) 1,," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 5(2), pages 60-71, February.
    • Handle: RePEc:adp:jomcij:v:5:y:2018:i:2:p:60-71
    DOI: 10.19080/OMCIJ.2018.05.555660
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