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Antioxidant and Antiapoptotic Effects of Fraxetin against Lead Induced Toxicity in Human Neuroblastoma Cells

Author

Listed:
  • Challa Suresh

    (Department of Biochemistry, National Institute of Nutrition, India)

  • Prasanna K Dixit

    (Department of Zoology, Berhampur University, India)

Abstract

Exposure to lead (Pb), a toxic heavy metal produces a wide range of adverse health effects. Both adults and children can suffer from the effects of Pb-poisoning, but childhood Pb-poisoning is much more frequent. Low-level Pb-exposure can result in reduced IQ, learning disabilities, attention deficit disorders, behavioural problems, stunted growth, impaired hearing, and kidney damage. Oxidative stress is proposed as an intracellular mechanism in Pb-induced toxicity, suggesting the fact that antioxidants might play a very important role in the treatment of Pb-poisoning. The present study was designed to investigate whether fraxetin (FXT), an important coumarin has a beneficial effect on human SH-SY5Y neuroblastoma cells exposed to Pb. In the present study, the cells were exposed to different concentrations (0.01-10 mM) of Pb for 48 hours to determine the concentration (IC50 = 5 mM) at which 50% inhibition in the viability of cells.

Suggested Citation

  • Challa Suresh & Prasanna K Dixit, 2018. "Antioxidant and Antiapoptotic Effects of Fraxetin against Lead Induced Toxicity in Human Neuroblastoma Cells," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 5(1), pages 1-6, January.
    • Handle: RePEc:adp:jomcij:v:5:y:2018:i:1:p:1-6
    DOI: 10.19080/OMCIJ.2018.05.555651
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