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Synthesis, Characterization & Biological Evaluation of Mutual Prodrugs of Some Selected NSAIDs conjugated with different antioxidant via different amino acids

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  • Sharma N

    (K N Modi Institute of Pharmaceutical Educational & Research, India)

Abstract

Some selected non-steroidal anti-inflammatory drugs (Aceclofenac, Diclofenac), have been conjugated with antioxidant (Guaiacol, Menthol) via Amino acid spacer (Phenylalanine, Glycine) which has anti-inflammatory, cytoprotective and immunomodulatory properties; therefore this conjugation will synergize the effect of the parent NSAIDs as anti-inflammatory drugs and reducing their gastric side effects. Four compounds have been synthesized andthe structure was confirmed by using IR, NMR (1H-NMR) & Characterized by some physicochemical properties including Melting point. IR data were recorded on Shimadzu FT-IR Spectrophotometer using KBr pellets method & 1H-NMR spectra in DMSO on Bruckerspectrospin-300 MHz using TMS as internal standard. The purity of the synthesized compounds was checked by its TLC. Developing solvents used for the process was [Methanol: Chloroform (2.5ml: 7.5ml)]. TLC plates were made by using Silica gel G & Silica gel GF.

Suggested Citation

  • Sharma N, 2017. "Synthesis, Characterization & Biological Evaluation of Mutual Prodrugs of Some Selected NSAIDs conjugated with different antioxidant via different amino acids," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 4(4), pages 69-73, November.
    • Handle: RePEc:adp:jomcij:v:4:y:2017:i:4:p:69-73
    DOI: 10.19080/OMCIJ.2017.04.555642
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