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The Furan Approach to the Synthesis of the (+)-Civet Constituent (+)-2-((2S,6S)-6-Methyltetrahydro-2H-Pyran-2-yl) Acetic Acid

Author

Listed:
  • Isela García
  • Fátima Garrido
  • Generosa Gómez
  • Yagamare Fall

    (Departamento de Química Orgánica, Facultad de Química and Instituto de Investigación Sanitaria Galicia Sur (IISGS), University of Vigo, Spain)

  • Alioune Fall
  • Mohamed Gaye

    (Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques: Université Cheikh Anta Diop de Dakar, Sénégal, Africa)

Abstract

We describe an efficient new approach for the synthesis of the civet constituent (2S,6S)-(6-Methyltetrahydropyran-2-yl) acetic acid from commercially available starting material using the furan approach, a methodology we developed some years ago, which is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular hetero Michael addition.

Suggested Citation

  • Isela García & Fátima Garrido & Generosa Gómez & Yagamare Fall & Alioune Fall & Mohamed Gaye, 2017. "The Furan Approach to the Synthesis of the (+)-Civet Constituent (+)-2-((2S,6S)-6-Methyltetrahydro-2H-Pyran-2-yl) Acetic Acid," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 4(4), pages 66-68, November.
    • Handle: RePEc:adp:jomcij:v:4:y:2017:i:4:p:66-68
    DOI: 10.19080/OMCIJ.2017.04.555641
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