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Facile Synthesis of Some Novel 1, 3, 4-Oxa diazole Derivatives Associated with Pyrimidine Core Unit as a Anti-Microbial Agents

Author

Listed:
  • Virupakshi Prabhakar

    (Faculty of Chemistry, Rajiv Gandhi University of knowledge technologies, India)

  • Sreenivasulu Peta
  • Srinivasula Reddy Maddula

    (Prajna Generics Private Limited, India)

Abstract

A new series of 2-(4-phenylpyrimidin-2-yl)-5-p-substituted-1, 3, 4-oxadiazole derivatives (8a-j) were synthesized after refluxing 4-phenylpyrimidine-2-carbohydrazide[6] with different aromatic/Heterocyclic carboxylic acids (7 a-j) in the presence of POCl3. The chemical structures of these compounds were confirmed by various physico-chemical methods viz. IR, [1] H-NMR, EI-Mass, [13] C-NMR analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram-positive and gram-negative bacterial strains and fungi strains. The compounds 8j, 8i and 8h shows highly significant antimicrobial activity as compared to the standard drug.

Suggested Citation

  • Virupakshi Prabhakar & Sreenivasulu Peta & Srinivasula Reddy Maddula, 2017. "Facile Synthesis of Some Novel 1, 3, 4-Oxa diazole Derivatives Associated with Pyrimidine Core Unit as a Anti-Microbial Agents," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 4(2), pages 31-36, November.
    • Handle: RePEc:adp:jomcij:v:4:y:2017:i:2:p:31-36
    DOI: 10.19080/OMCIJ.2017.04.555634
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