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Anti-Diarrhoeal Properties of Cis-9-Octadecenoic Acid Isolated From Landolphia Owariensis Plant

Author

Listed:
  • S Garba

    (Chemistry Department Nigerian Defence Academy, Africa)

  • I Garba

    (NNPC-Krpc Kaduna, Africa)

Abstract

The phytochemical screening and the antidiarrhoeal activities of the crude extracts from the leaves Landolphiaowariensis were carried out using standard methods. The results of the phytochemical screening showed that the plant contained alkaloids, saponins, tannins, flavonoids and glycosides. The results of the antidiarrhoeal screening of the crude extracts showed that Landolphiaowariensis exhibited zone of inhibition ranging from 15 mm to 35 mm against test microbes. Ethyl-acetate extract of the Landolphiawariensis being the most active fraction was subjected to column chromatography, leading to the isolation of single compound that showed a high activities (zone of inhibition from 8mm to 32mm) against these causative agents of diarrhoea (Salmonella Typhi, Shigella dysentriae and Escherichia Coli respectively). Spectroscopic analysis of the isolated compound using 1HNMR, 13CNMR, IR and GCMS showed that the compound was Cis-9-Octadecenoic acid. The result of this works therefore showed that the extract from the leaves of Landolphiaowariensis could be used for the treatment of diarrhoea and other diseases caused by targeted microorganisms.

Suggested Citation

  • S Garba & I Garba, 2017. "Anti-Diarrhoeal Properties of Cis-9-Octadecenoic Acid Isolated From Landolphia Owariensis Plant," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 3(4), pages 103-108, September.
    • Handle: RePEc:adp:jomcij:v:3:y:2017:i:4:p:103-108
    DOI: 10.19080/OMCIJ.2017.03.555619
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