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Novel Route for Synthesis of Anti - Hyperglycaemic Activity of Thiazolidine 2,4- Dione Derivatives As A Mannich Bases

Author

Listed:
  • Ramakrishna Vellalacheruvu
  • L K Ravindranath

    (Department of Chemistry, SK University, India)

  • R Sai Leela

    (College of Pharmacy, SK University, India)

Abstract

The mannish bases of Thiozolidine 2,4 -dione derivatives has come to lime light due to their multi functional biological activities. Thiazolidine-2,4-dione is an extensively explored hetero cyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications ,cancer, arthritis, inflammation, microbial infection, and melanoma. Present work, synthesise quinoline attached imidozoline derivative using (3 +2) cycloaddition via imine of quinoline and TOSMIC. These derivatives were converted to mannich bases of thiozolidine 2,4 one using knoevenagel condensation. The sulfonyl derivatives of thiozolidine 2, 4 -dione were also synthesized and characterized by using alkylation conditions.

Suggested Citation

  • Ramakrishna Vellalacheruvu & L K Ravindranath & R Sai Leela, 2017. "Novel Route for Synthesis of Anti - Hyperglycaemic Activity of Thiazolidine 2,4- Dione Derivatives As A Mannich Bases," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 3(2), pages 37-45, August.
    • Handle: RePEc:adp:jomcij:v:3:y:2017:i:2:p:37-45
    DOI: 10.19080/OMCIJ.2017.03.555607
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