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Chemistry and Biological Potential of Pyrimidine Derivatives: Study of Nucleosides with Pyrimidines

Author

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  • Mohammad Asif

    (Department of pharmacy, GRD (PG) Institute of Management and Technology, India)

Abstract

Much attention has been devoted to the preparation of nucleosides with pyrimidinic bases and their derivatives, especially uracils. Uracils are an important heterocycles because of their applications as bioactive compounds like 5-iodouridine, 2(S)-will-ardiine, zidovudine and tifluridine. This scaffold is of prime importance to chemists and biologists to yield diverse type of new molecules and screen these new entities for pharmacological activities. These synthesized molecules exhibited a variety of activities like antitumor, tuberculostatic, anti-diarrhea], anticonvulsants, antibacterial, antimicrobial, tyrosine kinase inhibitor, calcium channel antagonists, antileishmanial, diuretic, anti-inflammatory and analgesic etc. These observed activities systematic molecular manipulations have yielded several types of clinically used drugs like anti-cancer drug, nucleoside based anti-AIDs drugs, CNS acting drugs.

Suggested Citation

  • Mohammad Asif, 2017. "Chemistry and Biological Potential of Pyrimidine Derivatives: Study of Nucleosides with Pyrimidines," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 2(5), pages 113-124, June.
    • Handle: RePEc:adp:jomcij:v:2:y:2017:i:5:p:113-124
    DOI: 10.19080/OMCIJ.2017.02.555598
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