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Pharmaceutical and Biological Effects of Suramin and Potential of Its Derivatives and Analogues

Author

Listed:
  • Shwu-Chen Tsay
  • Nitesh K. Gupta

    (Department of Chemistry, National Tsing Hua University, Taiwan)

  • Sergey O Bachurin
  • Jih Ru Hwu

    (Department of Medical and Biological Chemistry, Institute of Physiologically Active Compounds, Russian Academy of Science, Russia)

Abstract

As a popular drug, suramin has attracted much attention for a century. It has an extensive record of clinical trials. This review article gives a brief introduction of its wide biological roles, remarkable pharmacological activities, and several side effects. Chemists and biological scientists have been working together for the design and synthesis of its derivatives and analogues. Some structure-activity relationships have been realized and provide guidelines for its prosperous development in the near future.

Suggested Citation

  • Shwu-Chen Tsay & Nitesh K. Gupta & Sergey O Bachurin & Jih Ru Hwu, 2017. "Pharmaceutical and Biological Effects of Suramin and Potential of Its Derivatives and Analogues," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 2(4), pages 72-76, May.
    • Handle: RePEc:adp:jomcij:v:2:y:2017:i:4:p:72-76
    DOI: 10.19080/OMCIJ.2017.02.555593
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