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Topical Salicylic acid and Lactic acid Microemulsion

Author

Listed:
  • Maher Aljamal
  • Ibrahim Kayali

    (BeitJala Pharmaceutical Company / Research and Development department, Palestine)

  • Mohammad Abul-Haj

    (Department of Chemistry, Palestine, Al- Quds university, Israel)

Abstract

Microemulsionsare used to solubilizing and improve an active pharmaceutical ingredientssolubility and permeability, such as those for topical absorption availability. The objective of this study was to prepare a microemulsion liquid composed of 12% salicylic acid and 4% of lactic acid using castor oil, Tween 80, propylene glycol, ethyl alcohol and purified water. Using the low energy emulsification technique; four pseudo ternary phase diagrams were constructed and studied for at least 75 days under a titration method using purified water (with or without propylene glycol), each phase diagram was investigated at 25°C, 37°C and 45°C. The phases include conventional emulsion, viscous and transparent/translucent microemulsion. The Results indicate a clear, thermodynamic microemulsion liquid obtained in each of the constructed phase diagrams at all temperatures of study. Using propylene glycol as a co-surfactant, lead to more stable microemulsionsby using low concentration of Tween 80. It was suggested that microemulsions of 12% Salicylic acid and 4% Lactic acid could be a suitable vehicle for topical treatment of psoriasis, scaly patches, ichthyoses, dandruff, corns, calluses, and wartson the hands or feet. This study may be useful in formulating a delivery system for the pharmaceutical industry as well as in cosmetics and personal care products.

Suggested Citation

  • Maher Aljamal & Ibrahim Kayali & Mohammad Abul-Haj, 2017. "Topical Salicylic acid and Lactic acid Microemulsion," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 2(3), pages 49-54, May.
    • Handle: RePEc:adp:jomcij:v:2:y:2017:i:3:p:49-54
    DOI: 10.19080/OMCIJ.2017.02.555587
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