IDEAS home Printed from https://ideas.repec.org/a/adp/jomcij/v2y2017i3p46-49.html
   My bibliography  Save this article

Design, Synthesis, and Biological Evaluation of Mutual Prodrugs of Some Selected NSAIDs

Author

Listed:
  • Nidhi Sharma

    (Dr. K N Modi Institute of Pharmacy & Research Centre, Modinagar, India)

  • Anil Kumar Sahdev
  • Vinit Raj

    (Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, India)

Abstract

Non-steroidal Anti-inflammatory drugs (Aceclofenac, Mefenamic acid) have conjugated with different antioxidants such as Thymol, Menthol which having antiulcerogenic activity with the NSAIDs- antioxidant mutual prodrug gastro sparing NSAIDs devoid of Ulcerogenic side effects. Two mutual Prodrugs have synthesized in which NSAIDs have been conjugated with different antioxidants by a glycolic acid spacer. The structure was confirmed by using IR, NMR (1H-NMR) & Characterized by some physicochemical properties including the Melting point. Titled compounds showed the significant protection towards inflammation as well as exhibited potential antibacterial activity.

Suggested Citation

  • Nidhi Sharma & Anil Kumar Sahdev & Vinit Raj, 2017. "Design, Synthesis, and Biological Evaluation of Mutual Prodrugs of Some Selected NSAIDs," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 2(3), pages 46-49, April.
    • Handle: RePEc:adp:jomcij:v:2:y:2017:i:3:p:46-49
    DOI: 10.19080/OMCIJ.2017.02.555586
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555586.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555586.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/OMCIJ.2017.02.555586?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:jomcij:v:2:y:2017:i:3:p:46-49. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.