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Synthesis, Drug Likeness and Antioxidant Activity of Analogues of L-Arginine

Author

Listed:
  • AinaOlayinka
  • Afolabi Ezekiel
  • Odumosu Patricia
  • Ojerinde Stephen

    (Department of Pharmaceutical chemistry, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria)

Abstract

Free radicals damage is responsible for the development many chronic health problems. 3 analogues of L-arginine were synthesized and their structures were confirmed with FTIR, 1H and 13C NMR. Molecular properties and bioactivity prediction of the synthesized compounds was carried out with molinspirationsoftware. The antioxidant activity of the synthesized compounds was evaluated in vitro using DPPH radical scavenging assay. The compounds obeyed Lipinsky rule of five and showed good bioactivity scores. The analogues A1-A3 exhibited low antiradical activity against with IC50 value of 631.06, 501.19 and 537.02μg/ml respectively

Suggested Citation

  • AinaOlayinka & Afolabi Ezekiel & Odumosu Patricia & Ojerinde Stephen, 2017. "Synthesis, Drug Likeness and Antioxidant Activity of Analogues of L-Arginine," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 1(5), pages 186-189, March.
    • Handle: RePEc:adp:jomcij:v:1:y:2017:i:5:p:186-189
    DOI: 10.19080/OMCIJ.2017.01.555574
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