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In vitro Evaluation of Antifungal Activity of Callicarpa macrophylla Vahl. Leaves

Author

Listed:
  • YC Tripathi
  • Nishat Anjum

    (Chemistry Division, Forest Research Institute, Dehradun, India)

  • Lokesh Upadhyay

    (Centre for Interdisciplinary Biomedical Research, Adesh University, Bathinda, Punjab, India)

Abstract

Aqueous extracts of leaves of Callicarpa macrophylla Vahl. traditionally known for medicinal value were evaluated for antifungal efficacy against six pathogenic fungi namely viz, Alternaria alternata, Aspergillus flavus, Aspergillus niger, Cladosporium cladosporidies , Drechslera halodes and Fusarium moniliforme by agar-well diffusion method. The minimum inhibitory concentration (MIC) was determined through the broth dilution method which was found in the range of 3.50 – 4.25 mg/ml. Aqueous extract of C. macrophylla leaves exhibited varying degrees of antifungal activity against all the six test fungi. Radial growth inhibition of at concentration of 5, 10, 20 and 30 mg/ml was much less than that of positive control. However, 40 and 50 mg/ml test concentration of extract was considerably effective on growth inhibition of all the test fungi. The study thus revealed the promising antifungal efficacy of C. macrophylla leaves and its potential for development of botanical fungicide.

Suggested Citation

  • YC Tripathi & Nishat Anjum & Lokesh Upadhyay, 2017. "In vitro Evaluation of Antifungal Activity of Callicarpa macrophylla Vahl. Leaves," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 1(4), pages 168-171, March.
  • Handle: RePEc:adp:jomcij:v:1:y:2017:i:4:p:168-171
    DOI: 10.19080/OMCIJ.2017.01.555571
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