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Correlation Analysis of Chitosan Physicochemical Parameters Determined by Different Methods

Author

Listed:
  • Tatiana Lyalina
  • Anastasia Zubareva
  • Sergey Lopatin

    (Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Russia)

  • Vitaly Zubov
  • Svetlana Sizova
  • Elena Svirshchevskaya

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russia)

Abstract

Chitosan is a natural biodegradable cationic polymer with a promising potency for different applications. Its use is limited by standardization problems related to chitosan nature. The aim of this work was to compare different methods of molecular weight (MW) and deacetylation degree (DD) determination using two chitosan series varied in MW and DD. The absolute DD appeared to be accurately determined by NMR, first derivative of UV-absorbance spectra analysis, or conductometric titration. Contrary to DD, MW estimated by viscosity, size exclusion chromatography, or asymmetric field flow fractionation did not provide comparable absolute MW values. At the same time, correlation between all the methods was extremely high (Pearson’s coefficient of correlation, r~1) showing that each of them is sensitive to the change in chitosan MW. Taken collectively it can be concluded that chitosan behaves in different conditions as a molecule with different MW. As MW determined by any of these methods and viscosity correlate highly significantly, viscosity as a directly determined value is recommended to be used as the main chitosan characteristic.

Suggested Citation

  • Tatiana Lyalina & Anastasia Zubareva & Sergey Lopatin & Vitaly Zubov & Svetlana Sizova & Elena Svirshchevskaya, 2017. "Correlation Analysis of Chitosan Physicochemical Parameters Determined by Different Methods," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 1(3), pages 74-82, January.
    • Handle: RePEc:adp:jomcij:v:1:y:2017:i:3:p:74-82
    DOI: 10.19080/OMCIJ.2017.01.555562
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