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Combination Therapy Including Metformin hydrochloride for the Treatment of Diabetes and Related Comorbidity: A Patent Filed Survey

Author

Listed:
  • Juan Manuel Germán Acacio

    (Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición SZ Universidad Nacional Autónoma de México (CIC-UNAM), México)

  • David Morales-Morales

    (Instituto de Química. Universidad Nacional Autónoma de México. Circuito Exterior S/N. Ciudad Universitaria. Coyoacán. C. P. 04510. México CDMX)

Abstract

Diabetes is a group of metabolic dysfunctions/disorders and specifically type 2 diabetes (T2D) constitutes ~90-95% of all diabetic patients. For its treatment, Metformin hydrochloride is the most preferred anti-hyperglycemic oral agent. Due to the complexity of T2D, the use of Metformin hydrochloride alone (monotherapy) as the first-line drug has resulted to be inadequate and the addition of a second or multiple agents is necessary. Thus, in the last years there has been an enormous interest in the development of new therapeutic agents, leading to a large number of inventions (patents) regarding alternative therapies involving the use of Metformin hydrochloride in the presence of a second or more agents for the treatment and care of T2D.

Suggested Citation

  • Juan Manuel Germán Acacio & David Morales-Morales, 2017. "Combination Therapy Including Metformin hydrochloride for the Treatment of Diabetes and Related Comorbidity: A Patent Filed Survey," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 1(3), pages 124-159, March.
    • Handle: RePEc:adp:jomcij:v:1:y:2017:i:3:p:124-159
    DOI: 10.19080/OMCIJ.2017.01.555569
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