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Dihydroquinazolinones as Potential Antiproliferative and Tumor Inhibiting agents

Author

Listed:
  • Kereyagalahally H Narasimhamurthy
  • Hanumappa Ananda
  • Kothanahally S SharathKumar
  • Kanchugarakoppal S Rangappa

    (Department of Studies in Chemistry, Manasagangotri, University of Mysore, India)

Abstract

2,3dihydroquinazolinone derivatives were screened for their antiproliferative activity, among all the synthesized molecules compound 3j with electron withdrawing substituents on phenyl ring displayed considerable cytotoxicity against HeLa, MCF7 and K562 cell lines with an IC50 value of 17.1, 31.5 and 25.3 μM, respectively. Further we carried out live dead fluorescence dye assay using calcein-AM and ethidium homodimer staining results further validate the capacity of compound 3j it induces apoptosis in HeLa cells. In addition, the potent compound 3j tested for tumor regression studies in Swiss albino mouse. Both in vitro and in vivo results revealed the significant antiproliferative activity of compound 3j in tumor cell lines and tumor tissue showed multifocal areas of necrosis and numerous number of apoptotic cells.

Suggested Citation

  • Kereyagalahally H Narasimhamurthy & Hanumappa Ananda & Kothanahally S SharathKumar & Kanchugarakoppal S Rangappa, 2016. "Dihydroquinazolinones as Potential Antiproliferative and Tumor Inhibiting agents," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 1(2), pages 64-69, July.
    • Handle: RePEc:adp:jomcij:v:1:y:2016:i:2:p:64-69
    DOI: 10.19080/OMCIJ.2016.01.555560
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