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Myeloid Sarcoma (Chloroma) An Uncommon Entity

Author

Listed:
  • Larisa Yarindy Jesús Mejenes

    (Department of Pediatrics. Regional General Hospital 1. Mexican Institute of Social Security, Querétaro, Mexico)

  • Mendoza-Revilla Diego Antonio

    (Department of Clinical Immunology and Allergy. Regional General Hospital 1. Mexican Institute of Social Security, Querétaro, Mexico)

  • Jiménez-Madrigal Víctor Gabriel

    (Department of Pediatrics. General Hospital of Zone 11. Mexican Institute of Social Security. Nuevo Laredo, Tamaulipas, Mexico)

  • Navarro-Munguía Jazmí
  • Margareth Sharon Hall Mondragón
  • Aguilera-López Ana Karina

    (Department of Clinical Immunology and Allergy. La Raza National Medical Center. Mexican Institute of Social Security, Mexico City, Mexico)

Abstract

Granulocytic Sarcoma or Myeloid Sarcoma (MS) is a solid tumor of myeloid origin and extramedullary location. Its incidence is estimated between 2.5 - 9.11% of patients with Acute Myeloid Leukemia, 60% of MS cases occur in children under 15 years of age. The clinical characteristics depend on its location and range from an asymptomatic lesion to organ dysfunction due to infiltration. It appears as a circumscribed or diffuse soft tissue mass infiltrating the bone, skin and/or peritoneum. Definitive diagnosis requires biopsy and immunohistochemical study, the most sensitive markers are CD43 and lysozyme, with expression in up to 100% of cases, myeloperoxidase, is expressed in 66-96% of cases. Treatment includes radiation therapy, surgery, or both, combined with a specific systemic chemotherapy regimen or allogeneic bone marrow transplantation. Recognition of this entity, a timely diagnosis and early treatment is a diagnostic challenge when it occurs in isolation.

Suggested Citation

  • Larisa Yarindy Jesús Mejenes & Mendoza-Revilla Diego Antonio & Jiménez-Madrigal Víctor Gabriel & Navarro-Munguía Jazmí & Margareth Sharon Hall Mondragón & Aguilera-López Ana Karina, 2020. "Myeloid Sarcoma (Chloroma) An Uncommon Entity," Juniper Online Journal of Orthopedic & Orthoplastic Surgery, Juniper Publishers Inc., vol. 2(5), pages 91-93, August.
    • Handle: RePEc:adp:jojoos:v:2:y:2020:i:5:p:91-93
    DOI: 10.19080/JOJOOS.2020.02.555597
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